Contributions
Abstract: P1674
Type: LB Poster
Abstract Category: Late Breaking News
Introduction: Neuromyelitis Optica Spectrum Disorder (NMOSD) and Multiple sclerosis (MS) are two different inflammatory demyelinating diseases of the Central Nervous System (CNS) which can affect optic nerves and spinal cord. These two entities should be distinguished as they have a different prognosis and treatment. In front of Optic Neuritis (ON) or myelitis, immunological tests are used to reach the right diagnosis. The positivity of NMO-IgG, an autoantibody directed against Aquaporin-4, supports the diagnosis of NMOSD.
We aim to screen the positivity of these autoantibodies in Tunisian patients with suspicion of Optico-Spinal Demyelination (OSD).
Patients and methods: We performed anti-NMO-IgG screening using Anti-Aquaporin-4 IIFT kit (Euroimmun®, Germany) in 60 patients with suspicion of OSD: 40 patients already diagnosed as optico-spinal MS (group 1) and 20 patients with non-MS OSD (ON, myelitis and brain MRI not suggestive of MS) (group 2). In Group 1, ON was present in all cases and myelitis was associated in 33 cases. Anomalies of brain"s white mater were detected in all cases. CSF Isofocusing showed IgG oligoclonal bands in 34/40 patients. In Group 2, ON was present in 13 cases and myelitis in 14 cases. Seven patients had both symptoms. Anomalies of brain"s white mater were detected in 11 cases. CSF Isofocusing showed IgG oligoclonal bands in only 5 cases.
Results: Anti-NMO-IgG were positive in two patients of group 2 (2 females aged 29 and 46 years) leading to the diagnostic of NMOSD. In one case, ON and myelitis were associated and in the other case myelitis was isolated. Brain"s Magnetic Resonance Images (MRI) were normal in both cases. Both had a normal profile in CSF isofocusing. Anti-NMO-IgG were negative in all cases of group1 (MS).
Conclusion: Our data show that anti-NMO-IgG are rare in Tunisian patients with suspicion of OSD. Patients with such neurological disorder can not currently be easily classified. Clinical follow with repeat MRI and re-analysis of sera should be informative.
Disclosure: Nothing to disclose
Abstract: P1674
Type: LB Poster
Abstract Category: Late Breaking News
Introduction: Neuromyelitis Optica Spectrum Disorder (NMOSD) and Multiple sclerosis (MS) are two different inflammatory demyelinating diseases of the Central Nervous System (CNS) which can affect optic nerves and spinal cord. These two entities should be distinguished as they have a different prognosis and treatment. In front of Optic Neuritis (ON) or myelitis, immunological tests are used to reach the right diagnosis. The positivity of NMO-IgG, an autoantibody directed against Aquaporin-4, supports the diagnosis of NMOSD.
We aim to screen the positivity of these autoantibodies in Tunisian patients with suspicion of Optico-Spinal Demyelination (OSD).
Patients and methods: We performed anti-NMO-IgG screening using Anti-Aquaporin-4 IIFT kit (Euroimmun®, Germany) in 60 patients with suspicion of OSD: 40 patients already diagnosed as optico-spinal MS (group 1) and 20 patients with non-MS OSD (ON, myelitis and brain MRI not suggestive of MS) (group 2). In Group 1, ON was present in all cases and myelitis was associated in 33 cases. Anomalies of brain"s white mater were detected in all cases. CSF Isofocusing showed IgG oligoclonal bands in 34/40 patients. In Group 2, ON was present in 13 cases and myelitis in 14 cases. Seven patients had both symptoms. Anomalies of brain"s white mater were detected in 11 cases. CSF Isofocusing showed IgG oligoclonal bands in only 5 cases.
Results: Anti-NMO-IgG were positive in two patients of group 2 (2 females aged 29 and 46 years) leading to the diagnostic of NMOSD. In one case, ON and myelitis were associated and in the other case myelitis was isolated. Brain"s Magnetic Resonance Images (MRI) were normal in both cases. Both had a normal profile in CSF isofocusing. Anti-NMO-IgG were negative in all cases of group1 (MS).
Conclusion: Our data show that anti-NMO-IgG are rare in Tunisian patients with suspicion of OSD. Patients with such neurological disorder can not currently be easily classified. Clinical follow with repeat MRI and re-analysis of sera should be informative.
Disclosure: Nothing to disclose