ECTRIMS eLearning

Cognitive impairment in patients with primary and progressive forms of multiple sclerosis
Author(s):
O. Mialovytska
,
O. Mialovytska
Affiliations:
Y. Khyzhniak
,
Y. Khyzhniak
Affiliations:
L. Sokolova
L. Sokolova
Affiliations:
ECTRIMS Learn. Dermendjiev S. 09/16/16; 146092; P1665
Svetlan Dermendjiev
Svetlan Dermendjiev
Contributions
Abstract

Abstract: P1665

Type: LB Poster

Abstract Category: Late Breaking News

Background: Prevalence of cognitive impairment in patients with multiple sclerosis (MS) ranges from 40 to 70%. Presence of cognitive dysfunction at the early stages of the disease is an unfavourable prognostic factor for the disease progression.

Objectives: To define the characteristics of cognitive impairment in MS patients

Methods: Cognitive impairment assessment was conducted using Montreal cognitive assessment scale (MoCA). Severity of the disease was determined using the Kurtzke Expanded Disability Status Scale (EDSS).

Results: 67 patients were examined: 3 - with radiologically isolated syndrome (RIS), 4 - with clinically isolated syndrome (CIS), 3 - with primary-progressive MS (PPMS), 50 - with relapsing-remitting MS (RRMS), 8 - with secondary-progressive MS (SPMS). Multiple analysis using Scheffé´s method of multiple comparison showed the following results in patients with CIS: a statistically significant difference was found between the induces of age and disease duration (F = 19,71, r˂0,01), age and degree of disability (F = 23,14, r˂0,01), age and cognitive status (F = 14,74, r˂0,01), degree of disability and cognitive status (F = 17,71, r˂0,01). When using univariate Kruskal-Wallis test with the help of Dan criteria in patients with RRMS, statistically significant difference was found between the indices of age and degree of disability (Q = 10,98, r˂0,01), age and disease duration (Q = 9,88 , r˂0,01), age and cognitive status (Q = 3,86, r˂0,01), degree of disability and cognitive status (Q = 7,14, r˂0,01), disease duration and cognitive status of patients (Q = 6,02, r˂0,01). Statistical analysis using Wilcoxon test in patients with SPMS found statistically significant difference between the indices of age and cognitive status (r˂0,001), degree of disability and cognitive status (r˂0,001), disease duration and cognitive status (r˂ 0.001).

Conclusions: Cognitive disorders are common among patients not only with definite MS, but can accompany CIS and RIS. Studies of cognitive impairment in patients with MS have prognostic value for determination of the severity of further disease progression.

Disclosure: Nothing to disclose

Abstract: P1665

Type: LB Poster

Abstract Category: Late Breaking News

Background: Prevalence of cognitive impairment in patients with multiple sclerosis (MS) ranges from 40 to 70%. Presence of cognitive dysfunction at the early stages of the disease is an unfavourable prognostic factor for the disease progression.

Objectives: To define the characteristics of cognitive impairment in MS patients

Methods: Cognitive impairment assessment was conducted using Montreal cognitive assessment scale (MoCA). Severity of the disease was determined using the Kurtzke Expanded Disability Status Scale (EDSS).

Results: 67 patients were examined: 3 - with radiologically isolated syndrome (RIS), 4 - with clinically isolated syndrome (CIS), 3 - with primary-progressive MS (PPMS), 50 - with relapsing-remitting MS (RRMS), 8 - with secondary-progressive MS (SPMS). Multiple analysis using Scheffé´s method of multiple comparison showed the following results in patients with CIS: a statistically significant difference was found between the induces of age and disease duration (F = 19,71, r˂0,01), age and degree of disability (F = 23,14, r˂0,01), age and cognitive status (F = 14,74, r˂0,01), degree of disability and cognitive status (F = 17,71, r˂0,01). When using univariate Kruskal-Wallis test with the help of Dan criteria in patients with RRMS, statistically significant difference was found between the indices of age and degree of disability (Q = 10,98, r˂0,01), age and disease duration (Q = 9,88 , r˂0,01), age and cognitive status (Q = 3,86, r˂0,01), degree of disability and cognitive status (Q = 7,14, r˂0,01), disease duration and cognitive status of patients (Q = 6,02, r˂0,01). Statistical analysis using Wilcoxon test in patients with SPMS found statistically significant difference between the indices of age and cognitive status (r˂0,001), degree of disability and cognitive status (r˂0,001), disease duration and cognitive status (r˂ 0.001).

Conclusions: Cognitive disorders are common among patients not only with definite MS, but can accompany CIS and RIS. Studies of cognitive impairment in patients with MS have prognostic value for determination of the severity of further disease progression.

Disclosure: Nothing to disclose

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