Contributions
Abstract: P1629
Type: LB Poster
Abstract Category: Late Breaking News
Background: Optic neuritis (ON) can result from many underlying conditions. Multiple sclerosis (MS) and neuromyelitis optica (NMO) are well-known causes of ON. There are, however, many unknown or not clearly understood underlying conditions, such as myelin oligodendrocyte glycoprotein antibodies (anti-MOG-Ab) related ON. Optical coherence tomography (OCT) can detect retinal nerve fiber layer (RNFL) and ganglion cell layer thinning after ON.
Objective: To investigate the thickness of peripapillary RNFL and macular ganglion cell-inner plexiform layers (GCIPL) using OCT in MS, NMO spectrum disorder with AQP4 antibody, and anti-MOG positive patients
Methods: Eighty-one previous ON eyes (43 NMO-ON, 10 MS-ON, 7 anti-MOG positive ON, and 21 idiopathic-ON) and 28 non-ON eyes (13 NMO, 8 MS, 1 anti-MOG positive, and 6 idiopathic-non-ON) were included in this study. All patients underwent SD-OCT imaging to analyze RNFL and GCIPL thickness after at least 3 months since the last episode of acute ON.
Results: Average RNFL and GCIPL thicknesses were thinner in NMO-ON, anti-MOG positive ON, and idiopathic-ON eyes when compared with those of MS-ON eyes ( p=0.006, p< 0.001, and p=0.041 respectively). All quadrants of RNFL and GCIPL thicknesses (except temporal thickness) of non-MS-ON eyes were significantly thinner than those of MS-ON eyes, especially superior quadrant of RNFL. There was no statistically significant difference for RNFL or GCIPL between the NMO-ON and anti-MOG positive ON groups. After the first episode of ON, mean average RNFL thickness decreased 33.71 µm, 53.2 µm, 13.86 µm, and 25.81 µm, and mean average GCIPL thickness decreased 26.489 µm, 32.4 µm, 11.536 µm, and 24.767 µm in NMO-ON, anti-MOG positive ON, MS-ON, and idiopathic-ON, respectively. After subsequent ON attacks, visual acuity, mean deviation of visual field, and RNFL thickness in the NMO-ON group showed a trend toward worsening, but the difference was not statistically significant.
Conclusions: OCT imaging for measurement of RNFL and GCIPL thickness is better than residual visual acuity and mean deviation of visual field for differentiating MS-ON from other types of ON. Superior thinning on RNFL analysis indicates non-MS previous ON. OCT may facilitate a decision regarding whether or not the patient should be treated long-term with disease-modifying therapies for MS or immunosuppressive agents for other types of optic neuritis.
Disclosure:
Nattapong Mekhasingharak: nothing to disclose
Poramaet Laowanapiban: nothing to disclose
Naraporn Prayoonwiwat: nothing to disclose
Sasitorn Siritho: nothing to disclose
Chanjira Satukijchai: nothing to disclose
Niphon Chirapapaisan: nothing to disclose
Abstract: P1629
Type: LB Poster
Abstract Category: Late Breaking News
Background: Optic neuritis (ON) can result from many underlying conditions. Multiple sclerosis (MS) and neuromyelitis optica (NMO) are well-known causes of ON. There are, however, many unknown or not clearly understood underlying conditions, such as myelin oligodendrocyte glycoprotein antibodies (anti-MOG-Ab) related ON. Optical coherence tomography (OCT) can detect retinal nerve fiber layer (RNFL) and ganglion cell layer thinning after ON.
Objective: To investigate the thickness of peripapillary RNFL and macular ganglion cell-inner plexiform layers (GCIPL) using OCT in MS, NMO spectrum disorder with AQP4 antibody, and anti-MOG positive patients
Methods: Eighty-one previous ON eyes (43 NMO-ON, 10 MS-ON, 7 anti-MOG positive ON, and 21 idiopathic-ON) and 28 non-ON eyes (13 NMO, 8 MS, 1 anti-MOG positive, and 6 idiopathic-non-ON) were included in this study. All patients underwent SD-OCT imaging to analyze RNFL and GCIPL thickness after at least 3 months since the last episode of acute ON.
Results: Average RNFL and GCIPL thicknesses were thinner in NMO-ON, anti-MOG positive ON, and idiopathic-ON eyes when compared with those of MS-ON eyes ( p=0.006, p< 0.001, and p=0.041 respectively). All quadrants of RNFL and GCIPL thicknesses (except temporal thickness) of non-MS-ON eyes were significantly thinner than those of MS-ON eyes, especially superior quadrant of RNFL. There was no statistically significant difference for RNFL or GCIPL between the NMO-ON and anti-MOG positive ON groups. After the first episode of ON, mean average RNFL thickness decreased 33.71 µm, 53.2 µm, 13.86 µm, and 25.81 µm, and mean average GCIPL thickness decreased 26.489 µm, 32.4 µm, 11.536 µm, and 24.767 µm in NMO-ON, anti-MOG positive ON, MS-ON, and idiopathic-ON, respectively. After subsequent ON attacks, visual acuity, mean deviation of visual field, and RNFL thickness in the NMO-ON group showed a trend toward worsening, but the difference was not statistically significant.
Conclusions: OCT imaging for measurement of RNFL and GCIPL thickness is better than residual visual acuity and mean deviation of visual field for differentiating MS-ON from other types of ON. Superior thinning on RNFL analysis indicates non-MS previous ON. OCT may facilitate a decision regarding whether or not the patient should be treated long-term with disease-modifying therapies for MS or immunosuppressive agents for other types of optic neuritis.
Disclosure:
Nattapong Mekhasingharak: nothing to disclose
Poramaet Laowanapiban: nothing to disclose
Naraporn Prayoonwiwat: nothing to disclose
Sasitorn Siritho: nothing to disclose
Chanjira Satukijchai: nothing to disclose
Niphon Chirapapaisan: nothing to disclose