Contributions
Abstract: P1618
Type: LB Poster
Abstract Category: Late Breaking News
Background: Multiple Sclerosis is a heterogeneous disorders involving in early stage gait and balance. Together with immunomodulating therapies, rehabilitation had a crucial role in improving motor tasks and life quality. Between the emerging techniques, Focal Vibrations (FV) could play a role, but they have been used in MS only to reduce muscle tone and fatigue alone or together with botulinum toxin.
Objective: To assess whether FV is effective on walking impairment in a cohort of MS patients.
Methods: We performed a single-centre randomized, double-blind, sham-controlled study to investigate efficacy of FV vs sham vibration in 20 RR MS patients. Ten patients received active device and ten patients the sham ones. Demographical, clinical and gait instrumental data analysis have been collected for each patient at baseline (T0), after treatment (T1) and after three weeks of wash out (T2).
Results: Both groups have no clinical and demographic differences. Treated patients showed significant improvements during the first right step (FRS) (p=0.007), average stride lenght (ASL) (p=0.012), double support right (DSRT) (p=0.016) and left (DSLT) (p=0.003) time. Non-treated patients didn´t show any significance for any dynamic variabile. Moreover on posturographic measurements we registered only a trend towards significance in swing area with eyes open (SAEO) (p=0.087). We also found in treated group significant improvements in FRT (p=0.018); BBS (p=0.037) and FSS scales (p=0.038) between T1 and T0. Lastly we found a significant inverse correlation in treated group between disease duration and percentage of improvement for DSLT (r=-0.775; p=0.014) in T1 vs T0 and percentage of improvement of FSS, with an inverse correlation with both disease duration (r=-0.775; p=0.014) and AGE (r=-0.733, p=0.025) in T1 vs T0
Conclusions: Our results suggested a beneficial effect of FV on walking impairment in MS patients suffering from spasticity and/or postural instability, partially lasted after follow up.
Disclosure:
Emanuele Spina: nothing to disclose
Antonio Carotenuto: nothing to disclose
Giuseppe Orefice: nothing to disclose
Rosa Iodice: nothing to disclose
Francesco Silvestre: nothing to disclose
Francesco Arace: nothing to disclose
Maria Gabriella Aceto: nothing to disclose
Ilaria Cerillo: nothing to disclose
Abstract: P1618
Type: LB Poster
Abstract Category: Late Breaking News
Background: Multiple Sclerosis is a heterogeneous disorders involving in early stage gait and balance. Together with immunomodulating therapies, rehabilitation had a crucial role in improving motor tasks and life quality. Between the emerging techniques, Focal Vibrations (FV) could play a role, but they have been used in MS only to reduce muscle tone and fatigue alone or together with botulinum toxin.
Objective: To assess whether FV is effective on walking impairment in a cohort of MS patients.
Methods: We performed a single-centre randomized, double-blind, sham-controlled study to investigate efficacy of FV vs sham vibration in 20 RR MS patients. Ten patients received active device and ten patients the sham ones. Demographical, clinical and gait instrumental data analysis have been collected for each patient at baseline (T0), after treatment (T1) and after three weeks of wash out (T2).
Results: Both groups have no clinical and demographic differences. Treated patients showed significant improvements during the first right step (FRS) (p=0.007), average stride lenght (ASL) (p=0.012), double support right (DSRT) (p=0.016) and left (DSLT) (p=0.003) time. Non-treated patients didn´t show any significance for any dynamic variabile. Moreover on posturographic measurements we registered only a trend towards significance in swing area with eyes open (SAEO) (p=0.087). We also found in treated group significant improvements in FRT (p=0.018); BBS (p=0.037) and FSS scales (p=0.038) between T1 and T0. Lastly we found a significant inverse correlation in treated group between disease duration and percentage of improvement for DSLT (r=-0.775; p=0.014) in T1 vs T0 and percentage of improvement of FSS, with an inverse correlation with both disease duration (r=-0.775; p=0.014) and AGE (r=-0.733, p=0.025) in T1 vs T0
Conclusions: Our results suggested a beneficial effect of FV on walking impairment in MS patients suffering from spasticity and/or postural instability, partially lasted after follow up.
Disclosure:
Emanuele Spina: nothing to disclose
Antonio Carotenuto: nothing to disclose
Giuseppe Orefice: nothing to disclose
Rosa Iodice: nothing to disclose
Francesco Silvestre: nothing to disclose
Francesco Arace: nothing to disclose
Maria Gabriella Aceto: nothing to disclose
Ilaria Cerillo: nothing to disclose