Contributions
Abstract: P1329
Type: Poster
Abstract Category: RIMS - Exercise
Purpose: To compare salivary cortisol, blood lactate levels and cardiovascular function in the acute recovery phase following different exercise modalities in persons with multiple sclerosis (MS) to healthy matched controls (CON).
Methods: 15 persons with MS and 17 CON were enrolled and matched for age, weight and BMI. All participants performed three different cycling exercise modalities, on separate days. The supervised exercise bouts consisted of; a) Cardio-pulmonary exercise test (CPET) to voluntary exhaustion; b) 30 min continuous cycling at 70-75% of peak heart rate (HR peak) and c) High Intensity Interval (HIT) session including 4*5 min at > 80% of HRpeak with 2 min between the intervals. Oxygen consumption (VO2), heart rate recovery (HRR), lactate and salivary cortisol levels were determined prior to each exercise bout, and were continuously assessed for 10 min after each bout. Lactate and Salivary samples were additionally collected 30 and 60 min post exercise.
Results: Resting HR, VO2 and lactate levels were significantly higher in the MS group (75bpm; 5.2+-1.13ml/kg/min; 2.2+-0.54mmol/l) compared to CON (62bpm; 4.1+-1.17ml/kg/min; 1.4+-0.44mmol/l (p< 0.05). CPET showed that VO2peak and peak lactate were significantly lower in MS (MS: 1877+-591.0ml/min; 7.1+-3.4mmol/l vs CON: 2657+-773.0ml/min, 9.7+-1.8mmol/l ; p< 0.05)VO2 and HR recovery was slowed in MS 60s, 120s and 5min post exercise (p< 0.05). Finally, there was a significant group x time interaction in the cortisol response to exercise showing attenuated post exercise cortisol response in MS to all timepoints (p< 0.05), but with no difference in resting cortisol levels.
Conclusion: Persons with MS have higher resting HR, VO2 and lactate levels than healthy age matched controls. In addition, persons with MS have prolonged VO2 and heart rate recovery after different aerobic exercise modalities as well as an attenuated cortisol response.
Disclosure: Martin Sloth Pedersen: Nothing to disclose
Ulrik Dalgas: Nothing to disclose
Jens Bansi: Nothing to disclose
Jürg Kesselring: Nothing to disclose
Abstract: P1329
Type: Poster
Abstract Category: RIMS - Exercise
Purpose: To compare salivary cortisol, blood lactate levels and cardiovascular function in the acute recovery phase following different exercise modalities in persons with multiple sclerosis (MS) to healthy matched controls (CON).
Methods: 15 persons with MS and 17 CON were enrolled and matched for age, weight and BMI. All participants performed three different cycling exercise modalities, on separate days. The supervised exercise bouts consisted of; a) Cardio-pulmonary exercise test (CPET) to voluntary exhaustion; b) 30 min continuous cycling at 70-75% of peak heart rate (HR peak) and c) High Intensity Interval (HIT) session including 4*5 min at > 80% of HRpeak with 2 min between the intervals. Oxygen consumption (VO2), heart rate recovery (HRR), lactate and salivary cortisol levels were determined prior to each exercise bout, and were continuously assessed for 10 min after each bout. Lactate and Salivary samples were additionally collected 30 and 60 min post exercise.
Results: Resting HR, VO2 and lactate levels were significantly higher in the MS group (75bpm; 5.2+-1.13ml/kg/min; 2.2+-0.54mmol/l) compared to CON (62bpm; 4.1+-1.17ml/kg/min; 1.4+-0.44mmol/l (p< 0.05). CPET showed that VO2peak and peak lactate were significantly lower in MS (MS: 1877+-591.0ml/min; 7.1+-3.4mmol/l vs CON: 2657+-773.0ml/min, 9.7+-1.8mmol/l ; p< 0.05)VO2 and HR recovery was slowed in MS 60s, 120s and 5min post exercise (p< 0.05). Finally, there was a significant group x time interaction in the cortisol response to exercise showing attenuated post exercise cortisol response in MS to all timepoints (p< 0.05), but with no difference in resting cortisol levels.
Conclusion: Persons with MS have higher resting HR, VO2 and lactate levels than healthy age matched controls. In addition, persons with MS have prolonged VO2 and heart rate recovery after different aerobic exercise modalities as well as an attenuated cortisol response.
Disclosure: Martin Sloth Pedersen: Nothing to disclose
Ulrik Dalgas: Nothing to disclose
Jens Bansi: Nothing to disclose
Jürg Kesselring: Nothing to disclose