Contributions
Abstract: P1314
Type: Poster
Abstract Category: Therapy - symptomatic - Enhancing CNS plasticity
Background: Imaging methods (especially functional magnetic resonance imaging - fMRI) are widely used for mapping of neuroplasticity in patients with multiple sclerosis (MS). They can contribute to better understanding and describing of pathological and repair processes in the brain as well as they can be used for objectification and evaluation of physiotherapy effect.
Aims: To contribute to the better understanding of the brain pathological processes in MS patients by analysing fMRI data (captured during watching kinetic video scenes). To compare these records with records of healthy controls and demonstrate the effect of facilitation physiotherapy by evaluating fMRI records (brain activation) and clinical features.
Methods: 39 patients with MS (mean age 46.7±12.3, Expanded Disability Status Scale - EDSS 4.3±1.7, disease duration 12.1±7.2 years) and 42 healthy volunteers (mean age 43.7±14.8 years) participated in the study. People with MS underwent a two-month program of facilitation physiotherapy (2x a week,1 hour). The clinical examination (evaluation of fine motor skills, balance, walk and cognitive functions) and fMRI examination while watching alternating kinetic and static video scenes were performed at the beginning and at the end of the program. FMRI data were analysed in software SPM8 (Statistical Parametric Mapping).
Results: The healthy controls had stronger activation in secondary visual cortex and cerebellum than MS patients while watching kinetic video (p=0.01). Statistically significant differences remain unchanged after physiotherapy. In healthy controls, there was found significant activation in the posterior areas of insula while watching static scenes. The pattern of activation after physiotherapy transforms - after therapy it is generally smaller. It has been shown that the activation while watching kinetic videos increases with the disease severity (rising EDDS), especially in the areas of middle frontal gyrus, angular gyrus, insula and precentral gyrus. In clinical trials, there was an improvement, most in the walk and cognitive tests.
Conclusions: Perception of kinetic events evokes lower brain activation in MS patients compared to healthy controls - especially in areas where information is processed. These differences are unchanged after two months of the physiotherapy. People with MS reduce the extent of activation patterns after physiotherapy. Clinical status of the patients slightly improved after physiotherapy.
Disclosure: Prochazkova M: nothing to disclose
Tintera J: nothing to disclose
Spanhelova S: nothing to disclose
Prokopiusova T: nothing to disclose
Angelova G: nothing to disclose
Hruskova N: nothing to disclose
Vavrova D: nothing to disclose
Rydlo J: nothing to disclose
Stetkarova I: nothing to disclose
Lippertova Grunova M: nothing to disclose
Rasova K: nothing to disclose
The study was realized due to the support of the Grant Agency, Czech Republic GA13-23940S, PRVOUK P34 and 260277/SVV/2016.
Abstract: P1314
Type: Poster
Abstract Category: Therapy - symptomatic - Enhancing CNS plasticity
Background: Imaging methods (especially functional magnetic resonance imaging - fMRI) are widely used for mapping of neuroplasticity in patients with multiple sclerosis (MS). They can contribute to better understanding and describing of pathological and repair processes in the brain as well as they can be used for objectification and evaluation of physiotherapy effect.
Aims: To contribute to the better understanding of the brain pathological processes in MS patients by analysing fMRI data (captured during watching kinetic video scenes). To compare these records with records of healthy controls and demonstrate the effect of facilitation physiotherapy by evaluating fMRI records (brain activation) and clinical features.
Methods: 39 patients with MS (mean age 46.7±12.3, Expanded Disability Status Scale - EDSS 4.3±1.7, disease duration 12.1±7.2 years) and 42 healthy volunteers (mean age 43.7±14.8 years) participated in the study. People with MS underwent a two-month program of facilitation physiotherapy (2x a week,1 hour). The clinical examination (evaluation of fine motor skills, balance, walk and cognitive functions) and fMRI examination while watching alternating kinetic and static video scenes were performed at the beginning and at the end of the program. FMRI data were analysed in software SPM8 (Statistical Parametric Mapping).
Results: The healthy controls had stronger activation in secondary visual cortex and cerebellum than MS patients while watching kinetic video (p=0.01). Statistically significant differences remain unchanged after physiotherapy. In healthy controls, there was found significant activation in the posterior areas of insula while watching static scenes. The pattern of activation after physiotherapy transforms - after therapy it is generally smaller. It has been shown that the activation while watching kinetic videos increases with the disease severity (rising EDDS), especially in the areas of middle frontal gyrus, angular gyrus, insula and precentral gyrus. In clinical trials, there was an improvement, most in the walk and cognitive tests.
Conclusions: Perception of kinetic events evokes lower brain activation in MS patients compared to healthy controls - especially in areas where information is processed. These differences are unchanged after two months of the physiotherapy. People with MS reduce the extent of activation patterns after physiotherapy. Clinical status of the patients slightly improved after physiotherapy.
Disclosure: Prochazkova M: nothing to disclose
Tintera J: nothing to disclose
Spanhelova S: nothing to disclose
Prokopiusova T: nothing to disclose
Angelova G: nothing to disclose
Hruskova N: nothing to disclose
Vavrova D: nothing to disclose
Rydlo J: nothing to disclose
Stetkarova I: nothing to disclose
Lippertova Grunova M: nothing to disclose
Rasova K: nothing to disclose
The study was realized due to the support of the Grant Agency, Czech Republic GA13-23940S, PRVOUK P34 and 260277/SVV/2016.