Contributions
Abstract: P1118
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Cognitive impairment (CI) is present in up to 70% of all patients with multiple sclerosis (MS). Magnetic resonance imaging (MRI) studies have shown that atrophy measures are better predictors of CI than white matter lesion volume in MS.
Objective: The objectives of this study are to investigate the global cortical atrophy (GCA) and medial temporal lobe atrophy (MTLA) in patients with relapsing-remitting multiple sclerosis (RRMS) and to explore the relationship between atrophy and cognitive performance.
Methods: Twenty two patients (mean age 38.8 ±10.1) underwent clinical, detailed neuropsychological and neuroimaging (MRI) examination. GCA and MTLA were assessed by visual MRI atrophy rating scales. The patients were classified in two groups: patients with cognitive impairment (CI) and cognitive preserved (CP) patients.
Results: Twelve (54.5%) MS patients were classified as having CI. GCA was significantly more pronounced in the group of patients with CI (p=0.001) in comparison with CP patients. Interestingly, MTLA was also significantly more prominent in the CI group than in CP patients (p=0.01). Verbal and non-verbal memory scores, as well as semantic verbal fluency were significantly correlated to MTLA. Several executive functioning measures were highly correlated to GCA, in addition to verbal and non-verbal memory. MOCA appeared to be a more sensitive neuropsychological scale for general cognitive functioning associated with cerebral atrophy in comparison with MMSE.
Conclusion: Our results showed that visual MRI atrophy rating scales could be a feasible and facile method for evaluation of MS patients in relation to cognitive impairment. GCA and MTLA were related to specifically impaired cognitive domains even in patients with mild RRMS.
Disclosure: Todor Kunchev: nothing to disclose
Shima Mehrabian: nothing to disclose
Margarita Raycheva: nothing to disclose
Latchezar Traykov: nothing to disclose
Abstract: P1118
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Cognitive impairment (CI) is present in up to 70% of all patients with multiple sclerosis (MS). Magnetic resonance imaging (MRI) studies have shown that atrophy measures are better predictors of CI than white matter lesion volume in MS.
Objective: The objectives of this study are to investigate the global cortical atrophy (GCA) and medial temporal lobe atrophy (MTLA) in patients with relapsing-remitting multiple sclerosis (RRMS) and to explore the relationship between atrophy and cognitive performance.
Methods: Twenty two patients (mean age 38.8 ±10.1) underwent clinical, detailed neuropsychological and neuroimaging (MRI) examination. GCA and MTLA were assessed by visual MRI atrophy rating scales. The patients were classified in two groups: patients with cognitive impairment (CI) and cognitive preserved (CP) patients.
Results: Twelve (54.5%) MS patients were classified as having CI. GCA was significantly more pronounced in the group of patients with CI (p=0.001) in comparison with CP patients. Interestingly, MTLA was also significantly more prominent in the CI group than in CP patients (p=0.01). Verbal and non-verbal memory scores, as well as semantic verbal fluency were significantly correlated to MTLA. Several executive functioning measures were highly correlated to GCA, in addition to verbal and non-verbal memory. MOCA appeared to be a more sensitive neuropsychological scale for general cognitive functioning associated with cerebral atrophy in comparison with MMSE.
Conclusion: Our results showed that visual MRI atrophy rating scales could be a feasible and facile method for evaluation of MS patients in relation to cognitive impairment. GCA and MTLA were related to specifically impaired cognitive domains even in patients with mild RRMS.
Disclosure: Todor Kunchev: nothing to disclose
Shima Mehrabian: nothing to disclose
Margarita Raycheva: nothing to disclose
Latchezar Traykov: nothing to disclose