Contributions
Abstract: P1110
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Atrophy of the corpus callosum, was often associated with different cognitive variables such as processing speed, verbal fluency, interhemispheric disconnection deficit or presence of fatigue.
Objectives: Investigate the relationship between total and regional corpus callosum (CC) atrophy and cognitive performance in patients with MS.
Method: 112 patients with MS were included; mean age 41±10 years, 74 women, schooling 12±3 years, mean disease duration 9±6 years, 104 Relapsing-Remitting forms and Expanded Disability Status Scale (EDSS) score 2.0 (median). All participants underwent brain magnetic resonance and comprehensive cognitive testing. Total and regional CC atrophy was measured with the corpus callosum index (CCI).
Results: Controlling for age and schooling, CCI was associated to information processing mesaures (Symbol Digit Modalities Test (p>0,001), Verbal Tracking Test (p=0,02), and Spatial Location (p=0,02)), verbal and visual memory (total recall of Selective Reminding Test (p>0,001), Logic Memory Test (p=0,01), Complex Figure Test (p=0,004) and 10/36 Spatial Recall Test (p< 0,001)), categorical fluency (p< 0,001), visuoperceptive organization (Hooper Visual Organization Test: p=0,01) and cognitive flexibility (Wisconsin Card Sorting Test: p=0,005). Anterior CC segment was associated to verbal, visual and working memory, Splenium was associated to attention, visuoperceptive organization and naming, and médium segment was associated to processing speed, memory and executive functions.
Discussion: Atrophy of the CC is related with cognitive dysfunction in MS. Regionally, different cognitive processes are associated to the three portions of CC suggesting a relative cognitive specialization. Naming, depending anterior areas, show association with splenium size suggesting a posterior areas intervention that help run this function.
Disclosure: Nothing to disclose
Abstract: P1110
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Atrophy of the corpus callosum, was often associated with different cognitive variables such as processing speed, verbal fluency, interhemispheric disconnection deficit or presence of fatigue.
Objectives: Investigate the relationship between total and regional corpus callosum (CC) atrophy and cognitive performance in patients with MS.
Method: 112 patients with MS were included; mean age 41±10 years, 74 women, schooling 12±3 years, mean disease duration 9±6 years, 104 Relapsing-Remitting forms and Expanded Disability Status Scale (EDSS) score 2.0 (median). All participants underwent brain magnetic resonance and comprehensive cognitive testing. Total and regional CC atrophy was measured with the corpus callosum index (CCI).
Results: Controlling for age and schooling, CCI was associated to information processing mesaures (Symbol Digit Modalities Test (p>0,001), Verbal Tracking Test (p=0,02), and Spatial Location (p=0,02)), verbal and visual memory (total recall of Selective Reminding Test (p>0,001), Logic Memory Test (p=0,01), Complex Figure Test (p=0,004) and 10/36 Spatial Recall Test (p< 0,001)), categorical fluency (p< 0,001), visuoperceptive organization (Hooper Visual Organization Test: p=0,01) and cognitive flexibility (Wisconsin Card Sorting Test: p=0,005). Anterior CC segment was associated to verbal, visual and working memory, Splenium was associated to attention, visuoperceptive organization and naming, and médium segment was associated to processing speed, memory and executive functions.
Discussion: Atrophy of the CC is related with cognitive dysfunction in MS. Regionally, different cognitive processes are associated to the three portions of CC suggesting a relative cognitive specialization. Naming, depending anterior areas, show association with splenium size suggesting a posterior areas intervention that help run this function.
Disclosure: Nothing to disclose