Contributions
Abstract: P1095
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neurophysiology
Background: The P300 (P3) wave is an event related potential (ERP) component elicited in the process of decision making. It is usually elicited using the oddball paradigm, in which low-probability target items are mixed with high-probability non-target (or "standard") items.
Methods: We performed a study of simultaneously recorded “primary” (VEPs) and “cognitive” (ERPs) visual evoked potentials in a group of Multiple Sclerosis (MS) patients who have no signs or symptoms of visual dysfunction. Two unidimensional Gabor patches (with a luminance profile of a sinusoid multiplied by a gaussian) of 1 cycle per degree of spatial frequency, differing in the orientation of the gratings (horizontal and vertical), was presented in an “odd-ball” paradigm to 30 patients with MS and 30 age-matched control subjects. We measured the latencies and amplitudes of N70, P100 and P300 components, and derived the “normalized” measures of P300-N70 latency difference (Central Processing Time - CPT70), the P300-P100 latency difference (CPT100) and the P300 amplitude responses normalized to either N70 and P100 amplitude. We evaluated the relationship between primary and cognitive processing abnormalities. Than we investigated whether or not patients with orientation-dependent VEP changes, which are thought to be due to cortical pathology, have VERPs abnormalities. Third, we investigated if individual orientation-specific VEPs and VERPs results correlate with selective neuropsychological test scores for visuoperceptual or visuospatial skills. A wide battery of neuropsychological tests was performed.
Results: We found a significant correlation (r=066, p< 0.01) only between the Stroop test and the raw and normalized (CPT) P-300 results.
Conclusions: The P300-P100 latency difference (CPT100), a visual electrophysiological measure of cognition that is not dependent on impaired transmission along the optic nerve pathways, is associated with Stroop Test in MS patients.
Disclosure: Christian Cordano reports a grant from the Italian Multiple Sclerosis Research Foundation (cod 2013/B74),
Luca Mazzella has nothing to disclose,
Carla Ogliastro has nothing to disclose,
Maria Cellerino has nothing to disclose,
Caterina Lapucci has nothing to disclose,
Lucilla Vestito has nothing to disclose,
Fabio Bandini has nothing to disclose.
Abstract: P1095
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - Neurophysiology
Background: The P300 (P3) wave is an event related potential (ERP) component elicited in the process of decision making. It is usually elicited using the oddball paradigm, in which low-probability target items are mixed with high-probability non-target (or "standard") items.
Methods: We performed a study of simultaneously recorded “primary” (VEPs) and “cognitive” (ERPs) visual evoked potentials in a group of Multiple Sclerosis (MS) patients who have no signs or symptoms of visual dysfunction. Two unidimensional Gabor patches (with a luminance profile of a sinusoid multiplied by a gaussian) of 1 cycle per degree of spatial frequency, differing in the orientation of the gratings (horizontal and vertical), was presented in an “odd-ball” paradigm to 30 patients with MS and 30 age-matched control subjects. We measured the latencies and amplitudes of N70, P100 and P300 components, and derived the “normalized” measures of P300-N70 latency difference (Central Processing Time - CPT70), the P300-P100 latency difference (CPT100) and the P300 amplitude responses normalized to either N70 and P100 amplitude. We evaluated the relationship between primary and cognitive processing abnormalities. Than we investigated whether or not patients with orientation-dependent VEP changes, which are thought to be due to cortical pathology, have VERPs abnormalities. Third, we investigated if individual orientation-specific VEPs and VERPs results correlate with selective neuropsychological test scores for visuoperceptual or visuospatial skills. A wide battery of neuropsychological tests was performed.
Results: We found a significant correlation (r=066, p< 0.01) only between the Stroop test and the raw and normalized (CPT) P-300 results.
Conclusions: The P300-P100 latency difference (CPT100), a visual electrophysiological measure of cognition that is not dependent on impaired transmission along the optic nerve pathways, is associated with Stroop Test in MS patients.
Disclosure: Christian Cordano reports a grant from the Italian Multiple Sclerosis Research Foundation (cod 2013/B74),
Luca Mazzella has nothing to disclose,
Carla Ogliastro has nothing to disclose,
Maria Cellerino has nothing to disclose,
Caterina Lapucci has nothing to disclose,
Lucilla Vestito has nothing to disclose,
Fabio Bandini has nothing to disclose.