Contributions
Abstract: P1088
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - OCT
Background: Foveal thickness may be a more sensitive indicator of primary retinal pathology than retinal nerve fiber layer thickness since the fovea contains no or sparse retinal nerve fiber layer, which coalesces into axons of the optic nerve. To our knowledge, few quantitative in vivo studies have investigated foveal thickness.
Objectives: By using optical coherence tomography (OCT), we measured foveal thickness to evaluate the intrinsic retinal pathology.
Methods: Patients with NMOSD (n=72) and age-matched healthy controls (n=34) underwent time-domain OCT and visual function testing.
Results: Seventy-two NMOSD patients (99 eyes with optic neuritis and 45 eyes without optic neuritis) and 34 age-matched controls were included. Foveal thinning was observed in both non-optic neuritis (185.1 µm, p< 0.001) and optic neuritis eyes (185.0 µm, p< 0.001) relative to control eyes (205.0 µm). Compared to controls, non-optic neuritis eyes did not have peripapillary retinal nerve fiber layer thinning but showed foveal thinning (p< 0.001). In NMOSD, foveal thickness correlated with disease duration, while RNFL thickness correlated with high or low contrast visual acuity, extended disability status scale, and disease duration.
Conclusions: In this study, we observed foveal thinning irrespective of optic neuritis, thus we believe that subclinical primary retinal pathology prior to retinal nerve fiber layer thinning may exist in NMOSD.
Disclosure: all authors: nothing to disclose
Abstract: P1088
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - OCT
Background: Foveal thickness may be a more sensitive indicator of primary retinal pathology than retinal nerve fiber layer thickness since the fovea contains no or sparse retinal nerve fiber layer, which coalesces into axons of the optic nerve. To our knowledge, few quantitative in vivo studies have investigated foveal thickness.
Objectives: By using optical coherence tomography (OCT), we measured foveal thickness to evaluate the intrinsic retinal pathology.
Methods: Patients with NMOSD (n=72) and age-matched healthy controls (n=34) underwent time-domain OCT and visual function testing.
Results: Seventy-two NMOSD patients (99 eyes with optic neuritis and 45 eyes without optic neuritis) and 34 age-matched controls were included. Foveal thinning was observed in both non-optic neuritis (185.1 µm, p< 0.001) and optic neuritis eyes (185.0 µm, p< 0.001) relative to control eyes (205.0 µm). Compared to controls, non-optic neuritis eyes did not have peripapillary retinal nerve fiber layer thinning but showed foveal thinning (p< 0.001). In NMOSD, foveal thickness correlated with disease duration, while RNFL thickness correlated with high or low contrast visual acuity, extended disability status scale, and disease duration.
Conclusions: In this study, we observed foveal thinning irrespective of optic neuritis, thus we believe that subclinical primary retinal pathology prior to retinal nerve fiber layer thinning may exist in NMOSD.
Disclosure: all authors: nothing to disclose