Contributions
Abstract: EP1575
Type: ePoster
Abstract Category: RIMS - Multi-disciplinary rehabilitation
Background: Exergaming is an emerging issue in neurorehabilitation. Video games contain elaborate reinforcement and rewards schedules that have the potential to maximize motivation. The accumbens nuclei (NAcc) are part of the dopaminergic pathways and areassociated with reward processing, motivation and avoidance attitude.
Objective: The aim of this study was to investigate whether NAcc connectivity predicts adherence to exergaming in multiple sclerosis (MS) by using resting-state functional magnetic resonance imaging (RS-fMRI).
Methods: We acquired MRI data from a group of patients participating to a rehabilitation program and from a group of healthy subjects (HS). Patients underwent a 12-week period of home-based rehabilitation on the Nintendo ® Wii balance board (WBB). Adherence to treatment (ADH) was defined as the percentage of time a patient accessed the gaming compared to time prescribed. The RS-fMRI was acquired with a 3 Tesla scanner soon before the beginning of the training. Neuroimaging data were analyzed using a seed-based method to identify the functional connectivity (FC) of the NAcc. Differences in the FC between the two groups were assessed with a two-sample T test (cluster level p< 0.05, FWE corrected). We used a one-sample model to calculate correlations between FC of the NAcc and ADH (cluster level p< 0.05, FWE corrected).
Results: After the exclusion of the low quality images (artefacts in the fronto-basal regions), data from 18 patients and 10 HS were included. Functional connectivity at rest of NAcc included the orbito-frontal, fronto-mesial and fronto-parietal associative cortices, basal ganglia, and cerebellum bilaterally. We did not find significative differences between groups in FC of NAcc. We found a negative correlation between ADH and NAcc connectivity with the cerebellum bilaterally, right posterior precuneus and left frontal pole in patient group.
Conclusions: Our findings suggest that high FC of NAcc with those areas may be deleterious in motivational processes related to exergaming.
Disclosure: The project was founded by the Italian MS society (grant 2012/R12)
LDG has nothing to disclose
LP has received consulting and/or lecture fees and travel grant from Bayer Schering, Biogen Idec, Genzyme, Bingen Idec, Novartis and Teva
NP has received from Biogen Idec
LC has received consulting fees from Almirall
SR has nothing to disclose
FT has nothing to disclose
CG has nothing to disclose
CP has received consulting and lecture fees from Bayer Schering, Biogen, Merck-Serono, Novartis, and Sanofi-Aventis; has received research funding from Bayer Schering, Merck Serono, Novartis, and Sanofi-Aventis.
PP has received founding for travel from Novartis, Genzyme and Bracco and speaker honoraria from Byogen
Abstract: EP1575
Type: ePoster
Abstract Category: RIMS - Multi-disciplinary rehabilitation
Background: Exergaming is an emerging issue in neurorehabilitation. Video games contain elaborate reinforcement and rewards schedules that have the potential to maximize motivation. The accumbens nuclei (NAcc) are part of the dopaminergic pathways and areassociated with reward processing, motivation and avoidance attitude.
Objective: The aim of this study was to investigate whether NAcc connectivity predicts adherence to exergaming in multiple sclerosis (MS) by using resting-state functional magnetic resonance imaging (RS-fMRI).
Methods: We acquired MRI data from a group of patients participating to a rehabilitation program and from a group of healthy subjects (HS). Patients underwent a 12-week period of home-based rehabilitation on the Nintendo ® Wii balance board (WBB). Adherence to treatment (ADH) was defined as the percentage of time a patient accessed the gaming compared to time prescribed. The RS-fMRI was acquired with a 3 Tesla scanner soon before the beginning of the training. Neuroimaging data were analyzed using a seed-based method to identify the functional connectivity (FC) of the NAcc. Differences in the FC between the two groups were assessed with a two-sample T test (cluster level p< 0.05, FWE corrected). We used a one-sample model to calculate correlations between FC of the NAcc and ADH (cluster level p< 0.05, FWE corrected).
Results: After the exclusion of the low quality images (artefacts in the fronto-basal regions), data from 18 patients and 10 HS were included. Functional connectivity at rest of NAcc included the orbito-frontal, fronto-mesial and fronto-parietal associative cortices, basal ganglia, and cerebellum bilaterally. We did not find significative differences between groups in FC of NAcc. We found a negative correlation between ADH and NAcc connectivity with the cerebellum bilaterally, right posterior precuneus and left frontal pole in patient group.
Conclusions: Our findings suggest that high FC of NAcc with those areas may be deleterious in motivational processes related to exergaming.
Disclosure: The project was founded by the Italian MS society (grant 2012/R12)
LDG has nothing to disclose
LP has received consulting and/or lecture fees and travel grant from Bayer Schering, Biogen Idec, Genzyme, Bingen Idec, Novartis and Teva
NP has received from Biogen Idec
LC has received consulting fees from Almirall
SR has nothing to disclose
FT has nothing to disclose
CG has nothing to disclose
CP has received consulting and lecture fees from Bayer Schering, Biogen, Merck-Serono, Novartis, and Sanofi-Aventis; has received research funding from Bayer Schering, Merck Serono, Novartis, and Sanofi-Aventis.
PP has received founding for travel from Novartis, Genzyme and Bracco and speaker honoraria from Byogen