Contributions
Abstract: EP1471
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Objective: To investigate the differences in the cognitive function and grey matter volume of patients with multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOsd).
Methods: Conventional brain magnetic resonance imaging (MRI), T1-weighted three-dimensional images and fluid attenuated inversion recovery were performed on all study participants. Neuropsychological tests including the Wechsler Adult Intelligence Scale-Ⅲ, the Wechsler Memory Scale-Revised, Trail Making Test (TMT) and Clinical Assessment for Attention (CAT) were administered to the patients within 6 months from the original MRI. The subjects that relapsed within 1 month from tests were excluded from the study. All neuropsychological test results and demographic values were compared between MS and NMOsd patient groups. Lesions in each T1-weighted imaging plaques were filled using an automated tool provided by Lesion Segmentation Tool and subsequently treated using voxel-based morphometry 8. To assess differences between the MS and NMOsd patients, parametric grey matter volume images were compared by the Statistical Parametric Mapping software 8, using age as the covariate for two-tailed t-test.
Results: A total of 20 relapsing-remitting MS and 16 NMOsd patients were included in this study. The median age of patients undergoing MRI scan was significantly lower in MS (38.5 years) than NMOsd patients (55.0 years; P = 0.012). Processing speed, general memory, verbal memory and delayed recall were found to be significantly decreased in MS patients (P = 0.036, 0.024, 0.012 and 0.013, respectively). No differences were observed in the Kurtzke"s expanded disability status scale and disease duration between the two groups. Meanwhile, both CAT and TMT, attention tests other than processing speed, were comparable between MS and NMOsd groups. The grey matter volume of the left superior temporal gyrus in MS patients was found to be decreased compared with that in NMOsd patients (P < 0.05, family-wise error corrected, Zmax = 4.97, 62 voxel).
Conclusions: It was evident that MS patients demonstrated decreased verbal memory and delayed recall compared to NMOsd patients, regardless of their lower age. Moreover, the loss of cortical volume in the left superior temporal gyrus of MS patients may be associated with cognitive impairments.
Disclosure: Hiroki Masuda: nothing to disclose
Masahiro Mori: nothing to disclose
Shigeki Hirano: nothing to disclose
Akiyuki Uzawa: nothing to disclose
Tomohiko Uchida: nothing to disclose
Ryohei Otani: nothing to disclose
Nobuyoshi Takahashi: nothing to disclose
Satoshi Kuwabara: nothing to disclose
Abstract: EP1471
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Objective: To investigate the differences in the cognitive function and grey matter volume of patients with multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOsd).
Methods: Conventional brain magnetic resonance imaging (MRI), T1-weighted three-dimensional images and fluid attenuated inversion recovery were performed on all study participants. Neuropsychological tests including the Wechsler Adult Intelligence Scale-Ⅲ, the Wechsler Memory Scale-Revised, Trail Making Test (TMT) and Clinical Assessment for Attention (CAT) were administered to the patients within 6 months from the original MRI. The subjects that relapsed within 1 month from tests were excluded from the study. All neuropsychological test results and demographic values were compared between MS and NMOsd patient groups. Lesions in each T1-weighted imaging plaques were filled using an automated tool provided by Lesion Segmentation Tool and subsequently treated using voxel-based morphometry 8. To assess differences between the MS and NMOsd patients, parametric grey matter volume images were compared by the Statistical Parametric Mapping software 8, using age as the covariate for two-tailed t-test.
Results: A total of 20 relapsing-remitting MS and 16 NMOsd patients were included in this study. The median age of patients undergoing MRI scan was significantly lower in MS (38.5 years) than NMOsd patients (55.0 years; P = 0.012). Processing speed, general memory, verbal memory and delayed recall were found to be significantly decreased in MS patients (P = 0.036, 0.024, 0.012 and 0.013, respectively). No differences were observed in the Kurtzke"s expanded disability status scale and disease duration between the two groups. Meanwhile, both CAT and TMT, attention tests other than processing speed, were comparable between MS and NMOsd groups. The grey matter volume of the left superior temporal gyrus in MS patients was found to be decreased compared with that in NMOsd patients (P < 0.05, family-wise error corrected, Zmax = 4.97, 62 voxel).
Conclusions: It was evident that MS patients demonstrated decreased verbal memory and delayed recall compared to NMOsd patients, regardless of their lower age. Moreover, the loss of cortical volume in the left superior temporal gyrus of MS patients may be associated with cognitive impairments.
Disclosure: Hiroki Masuda: nothing to disclose
Masahiro Mori: nothing to disclose
Shigeki Hirano: nothing to disclose
Akiyuki Uzawa: nothing to disclose
Tomohiko Uchida: nothing to disclose
Ryohei Otani: nothing to disclose
Nobuyoshi Takahashi: nothing to disclose
Satoshi Kuwabara: nothing to disclose