Contributions
Abstract: EP1465
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Introduction: Cognitive impairment is an important predictor of quality of life at all stages of Multiple Sclerosis (MS). Magnetic Resonance Imaging (MRI) markers have been used to associate tissue damage with cognitive dysfunction.
Objective: The aim of the study was to designate the MRI marker that predicts cognitive decline and explore its effect on every day activities in SPMS patients.
Methods: 30 SPMS patients and 31 healthy participants underwent neuropsychological assessment using the Trail Making Test (TMT) parts A and B, semantic and phonological verbal fluency task and a computerized cognitive screening battery (Central Nervous System Vital Signs). Everyday activities were evaluated with the instrumental activities of daily living (IADL) scale. Brain MRI was performed in all participants. We measured total lesion volume, third ventricle width, corpus callosum and thalamic area.
Comparisons between RRMS and controls were investigated on each neuropsychological and MRI measure using t-test and Mann-Whitney U test. Pearson correlation coefficients and Spearman rank correlation coefficients were calculated for all measures in both groups. We conducted a stepwise regression analysis using as dependent variable the IADL. We then used as dependent variables the neuropsychological measures that appeared from the previous regressions to be the best predictors for IADL, and proceeded with a stepwise analysis using all MRI measures as independent variables.
Results: The frequency of cognitive dysfunction for our SPMS patients was 80%. SPMS patients differed significantly from controls on all neuropsychological measures. Third ventricle width had a correlation with phonological verbal fluency task, processing speed, cognitive flexibility and executive functions. Phonological verbal fluency task, processing speed and psychomotor speed were the most sensitive markers for IADL.
Third ventricle width was the most sensitive MRI marker for processing speed and phonological verbal fluency task.
Conclusion: Third ventricle width predicts the clinically meaningful cognitive decline in our SPMS patients.
Disclosure:
Athanasios Papathanasiou: nothing to disclose
Lambros Messinis: nothing to disclose
Petros Zampakis: nothing to disclose
Panagiotis Papathanasopoulos: nothing to disclose
Abstract: EP1465
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Introduction: Cognitive impairment is an important predictor of quality of life at all stages of Multiple Sclerosis (MS). Magnetic Resonance Imaging (MRI) markers have been used to associate tissue damage with cognitive dysfunction.
Objective: The aim of the study was to designate the MRI marker that predicts cognitive decline and explore its effect on every day activities in SPMS patients.
Methods: 30 SPMS patients and 31 healthy participants underwent neuropsychological assessment using the Trail Making Test (TMT) parts A and B, semantic and phonological verbal fluency task and a computerized cognitive screening battery (Central Nervous System Vital Signs). Everyday activities were evaluated with the instrumental activities of daily living (IADL) scale. Brain MRI was performed in all participants. We measured total lesion volume, third ventricle width, corpus callosum and thalamic area.
Comparisons between RRMS and controls were investigated on each neuropsychological and MRI measure using t-test and Mann-Whitney U test. Pearson correlation coefficients and Spearman rank correlation coefficients were calculated for all measures in both groups. We conducted a stepwise regression analysis using as dependent variable the IADL. We then used as dependent variables the neuropsychological measures that appeared from the previous regressions to be the best predictors for IADL, and proceeded with a stepwise analysis using all MRI measures as independent variables.
Results: The frequency of cognitive dysfunction for our SPMS patients was 80%. SPMS patients differed significantly from controls on all neuropsychological measures. Third ventricle width had a correlation with phonological verbal fluency task, processing speed, cognitive flexibility and executive functions. Phonological verbal fluency task, processing speed and psychomotor speed were the most sensitive markers for IADL.
Third ventricle width was the most sensitive MRI marker for processing speed and phonological verbal fluency task.
Conclusion: Third ventricle width predicts the clinically meaningful cognitive decline in our SPMS patients.
Disclosure:
Athanasios Papathanasiou: nothing to disclose
Lambros Messinis: nothing to disclose
Petros Zampakis: nothing to disclose
Panagiotis Papathanasopoulos: nothing to disclose