Abstract: EP1462
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - Neurophysiology
Background: The aim of this study was to determine changes of tongue somatosensory evoked potentials (tSSEP) in a large cohort of patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS).
Methods: One hundred and five CIS patients were included in this study (75 females), with the mean age of 32.4±8.6. tSSEP and brain MRI were performed for each patient. P1 latencies and morphology of the main component (N1-P1-N2 complex) were analyzed. The results were interpreted according to normal values of our laboratory and interpreted as conduction block (when no repeatable response could be obtained), abnormal wave morphology (absence of N1 or N2 wave) and prolonged latencies of the P1 wave.
Results: For the right response 12 (11,4%), 21 (20,0%) and 8 (7,6%) patients had conduction block, abnormal wave morphology and prolonged latencies, respectively. For the left response 13 (12,4%), 25 (23,8%) and 9 (8,6%) patients had conduction block, abnormal wave morphology and prolonged latencies, respectively. Altogether, conduction block on at least one side was present in 21(20,0%) patients. Neurological examination revealed brainstem involvement in 18 (17,1%) patients. Conduction block was more frequent in patients with clinical evidence of brainstem involvement (p=0.047). Brainstem MRI lesions were present in 44 (41,9%) patients (15 (14,3%) had midbrain, 33 (31,4%) had pons and 15 (14,3%) had medulla oblongata lesions). There was no difference in P1 latencies between patients with or without brainstem lesions. Patients with brainstem (midbrain, pons and medulla oblongata) lesions had conduction blocks more frequently (p=0,003 (p=0,011, p=0,008, p=0,011), respectively).
Conclusion: Changes in tSSEP are frequently present in patients with CIS. Absent tSSEP response is more frequent in patients with brainstem involvement, both clinical and MRI.
Disclosure: Funding: Croatian Science Foundation grant HRZZ UIP-11-2013-2622
Abstract: EP1462
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - Neurophysiology
Background: The aim of this study was to determine changes of tongue somatosensory evoked potentials (tSSEP) in a large cohort of patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS).
Methods: One hundred and five CIS patients were included in this study (75 females), with the mean age of 32.4±8.6. tSSEP and brain MRI were performed for each patient. P1 latencies and morphology of the main component (N1-P1-N2 complex) were analyzed. The results were interpreted according to normal values of our laboratory and interpreted as conduction block (when no repeatable response could be obtained), abnormal wave morphology (absence of N1 or N2 wave) and prolonged latencies of the P1 wave.
Results: For the right response 12 (11,4%), 21 (20,0%) and 8 (7,6%) patients had conduction block, abnormal wave morphology and prolonged latencies, respectively. For the left response 13 (12,4%), 25 (23,8%) and 9 (8,6%) patients had conduction block, abnormal wave morphology and prolonged latencies, respectively. Altogether, conduction block on at least one side was present in 21(20,0%) patients. Neurological examination revealed brainstem involvement in 18 (17,1%) patients. Conduction block was more frequent in patients with clinical evidence of brainstem involvement (p=0.047). Brainstem MRI lesions were present in 44 (41,9%) patients (15 (14,3%) had midbrain, 33 (31,4%) had pons and 15 (14,3%) had medulla oblongata lesions). There was no difference in P1 latencies between patients with or without brainstem lesions. Patients with brainstem (midbrain, pons and medulla oblongata) lesions had conduction blocks more frequently (p=0,003 (p=0,011, p=0,008, p=0,011), respectively).
Conclusion: Changes in tSSEP are frequently present in patients with CIS. Absent tSSEP response is more frequent in patients with brainstem involvement, both clinical and MRI.
Disclosure: Funding: Croatian Science Foundation grant HRZZ UIP-11-2013-2622