Contributions
Abstract: EP1461
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - OCT
Objective: Evaluation of the validity of retinal nerve fiber layer (RNFL) thickness assessed by optical coherence tomography (OCT) of the 4th generation as a surrogate marker for neuroaxonal damage in the disease course of MS patients.
Methods: Prospective, monocenter study of expected 12 months with assessments at BL (T0) and at 12-month follow-up (T12). 190 MS patients of any entity (relapsing and progressive forms; mean age: 43.01yr ± 11.83) cared at an ambulant MS center (Mc Donald criteria, aged 19-73yr, EDSS 0-6.5, irrespective of MS treatment) underwent clinical assessment, neuropsychological testing and OCT at T0 and T12. Nearly a fifth of the patients received a MRI as well.
Outcomes: Correlation of OCT parameters (RNFL - right (r), left (l), bilateral (b)), Total Macula Volume (TMV - r, l, b) to clinical parameters (age, EDSS, disease duration, relapses), neuropsychological variables (Digit Span, Corsi Block, Tower of London and a computer-based memory and attention test - MAT) and MRI correlates (atrophy, MPRAGE) at baseline/T0 with regard to brain atrophy. In addition, validation of specific factors indexing neurodegeneration by multivariate regression analysis will take place.
Results: In the whole sample, highly significant inverse correlations were found between RNFL and TMV to clinical parameters EDSS (p< 0.0004) and disease duration (p< 0.009), whereas relapses only showed a trend (p< 0.09). Among MRI parameters, cortical white matter volume (cwmv; p< 0.04), subcortical grey matter volume (sgmv; p< 0.02) and total grey matter volume (tgmv; p< 0.04) provided the most consistent correlation to RNFL and TMV. No significant correlations were detectable between OCT and neuropsychological testing.
Subgroup analysis (EDSS < 3 vs. EDSS ≥ 3) showed significant correlations of OCT with EDSS and disease duration and with the MRI parameter sgmv only for the EDSS < 3 subgroup.
Conclusion:
(1) The correlations of OCT with MRI and clinical parameters indicate that OCT might be a useful additional technique to follow the clinical course and predict brain atrophy and neurodegeneration in MS.
(2) It is assumed that RNFL is more sensitive than TMV with respect to this objective.
(3) The follow up observations will show whether the targeted parameters show sensitivity in the longitudinal course of MS disease.
Disclosure:
Christopher Behrens: This initiated trial is supported by an investigational grant of Novartis AG.
Martin Tisch: nothing to disclose
Katja Sebald: nothing to disclose
Timm Oberwahrenbrock: nothing to disclose
Hanna Zimmermann: nothing to disclose
Michael Lang: nothing to disclose
Iris-Katharina Penner: nothing to disclose
Hermann Gümbel: nothing to disclose
Markus Palmbach: nothing to disclose
Friedemann Paul: nothing to disclose
Herbert Schreiber: nothing to disclose
Abstract: EP1461
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - OCT
Objective: Evaluation of the validity of retinal nerve fiber layer (RNFL) thickness assessed by optical coherence tomography (OCT) of the 4th generation as a surrogate marker for neuroaxonal damage in the disease course of MS patients.
Methods: Prospective, monocenter study of expected 12 months with assessments at BL (T0) and at 12-month follow-up (T12). 190 MS patients of any entity (relapsing and progressive forms; mean age: 43.01yr ± 11.83) cared at an ambulant MS center (Mc Donald criteria, aged 19-73yr, EDSS 0-6.5, irrespective of MS treatment) underwent clinical assessment, neuropsychological testing and OCT at T0 and T12. Nearly a fifth of the patients received a MRI as well.
Outcomes: Correlation of OCT parameters (RNFL - right (r), left (l), bilateral (b)), Total Macula Volume (TMV - r, l, b) to clinical parameters (age, EDSS, disease duration, relapses), neuropsychological variables (Digit Span, Corsi Block, Tower of London and a computer-based memory and attention test - MAT) and MRI correlates (atrophy, MPRAGE) at baseline/T0 with regard to brain atrophy. In addition, validation of specific factors indexing neurodegeneration by multivariate regression analysis will take place.
Results: In the whole sample, highly significant inverse correlations were found between RNFL and TMV to clinical parameters EDSS (p< 0.0004) and disease duration (p< 0.009), whereas relapses only showed a trend (p< 0.09). Among MRI parameters, cortical white matter volume (cwmv; p< 0.04), subcortical grey matter volume (sgmv; p< 0.02) and total grey matter volume (tgmv; p< 0.04) provided the most consistent correlation to RNFL and TMV. No significant correlations were detectable between OCT and neuropsychological testing.
Subgroup analysis (EDSS < 3 vs. EDSS ≥ 3) showed significant correlations of OCT with EDSS and disease duration and with the MRI parameter sgmv only for the EDSS < 3 subgroup.
Conclusion:
(1) The correlations of OCT with MRI and clinical parameters indicate that OCT might be a useful additional technique to follow the clinical course and predict brain atrophy and neurodegeneration in MS.
(2) It is assumed that RNFL is more sensitive than TMV with respect to this objective.
(3) The follow up observations will show whether the targeted parameters show sensitivity in the longitudinal course of MS disease.
Disclosure:
Christopher Behrens: This initiated trial is supported by an investigational grant of Novartis AG.
Martin Tisch: nothing to disclose
Katja Sebald: nothing to disclose
Timm Oberwahrenbrock: nothing to disclose
Hanna Zimmermann: nothing to disclose
Michael Lang: nothing to disclose
Iris-Katharina Penner: nothing to disclose
Hermann Gümbel: nothing to disclose
Markus Palmbach: nothing to disclose
Friedemann Paul: nothing to disclose
Herbert Schreiber: nothing to disclose