Contributions
Abstract: EP1460
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - OCT
Background: The optic nerve and the visual pathways are commonly involved, and often the first site of involvement in multiple sclerosis. Visual evoked potentials (VEP) and spectral-domain optical coherence tomography (SDOCT) are common ancillary studies that assess the visual pathways from a functional and structural aspect, respectively. VEP assesses visual pathway by measuring the latencies, amplitudes and symmetry of cortical responses to standardized visual stimuli. SDOCT, however, assesses structural changes in the retina arising from axonal loss and neurodegeneration.
Objectives: To determine the sensitivity of pattern-reversal VEP to SDOCT and the correlation between retinal nerve fiber layer (RNFL), ganglion cell/inner plexiform layer (GCIPL) with VEP latency in early relapsing-remitting multiple sclerosis.
Methods: A cross-sectional study of 100 eyes with disease duration of less than 5 years. Correlation analysis between retinal nerve fiber layer and ganglion-cell/inner plexiform layer with visual evoked potentials amplitude and latency.
Results: The sensitivity of VEP in detecting lesions was 56 % while that of SDOCT was 48% in all eyes. There was significant negative correlations between the average RNFL (r= -0.34, p =0.001) and GCIPL (r=-0.39, p< 0.001) with VEP latency. In eyes with prior optic neuritis, a significant negative correlation was seen between average RNFL (r=-0.33, p =0.037) and GCIPL (r=-0.40, p=0.010) with VEP latency, while in eyes with no prior optic neuritis, only the temporal quadrant RNFL (r=-0.28, p =0.028) correlated with VEP latency.
Conclusions: Visual evoked potential is more sensitive than spectral-domain optical coherence tomography in detecting visual pathway lesions in early relapsing-remitting multiple sclerosis. In these patients, there was correlation between RNFL, especially in the temporal RNFL quadrant with VEP latency in eyes with and without optic neuritis. GCIPL, correlated with with VEP latency only in eyes with prior optic neuritis.
Disclosure: The authors have no financial conflict to disclose
Abstract: EP1460
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - OCT
Background: The optic nerve and the visual pathways are commonly involved, and often the first site of involvement in multiple sclerosis. Visual evoked potentials (VEP) and spectral-domain optical coherence tomography (SDOCT) are common ancillary studies that assess the visual pathways from a functional and structural aspect, respectively. VEP assesses visual pathway by measuring the latencies, amplitudes and symmetry of cortical responses to standardized visual stimuli. SDOCT, however, assesses structural changes in the retina arising from axonal loss and neurodegeneration.
Objectives: To determine the sensitivity of pattern-reversal VEP to SDOCT and the correlation between retinal nerve fiber layer (RNFL), ganglion cell/inner plexiform layer (GCIPL) with VEP latency in early relapsing-remitting multiple sclerosis.
Methods: A cross-sectional study of 100 eyes with disease duration of less than 5 years. Correlation analysis between retinal nerve fiber layer and ganglion-cell/inner plexiform layer with visual evoked potentials amplitude and latency.
Results: The sensitivity of VEP in detecting lesions was 56 % while that of SDOCT was 48% in all eyes. There was significant negative correlations between the average RNFL (r= -0.34, p =0.001) and GCIPL (r=-0.39, p< 0.001) with VEP latency. In eyes with prior optic neuritis, a significant negative correlation was seen between average RNFL (r=-0.33, p =0.037) and GCIPL (r=-0.40, p=0.010) with VEP latency, while in eyes with no prior optic neuritis, only the temporal quadrant RNFL (r=-0.28, p =0.028) correlated with VEP latency.
Conclusions: Visual evoked potential is more sensitive than spectral-domain optical coherence tomography in detecting visual pathway lesions in early relapsing-remitting multiple sclerosis. In these patients, there was correlation between RNFL, especially in the temporal RNFL quadrant with VEP latency in eyes with and without optic neuritis. GCIPL, correlated with with VEP latency only in eyes with prior optic neuritis.
Disclosure: The authors have no financial conflict to disclose