Contributions
Abstract: EP1451
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - Imaging
Background: Multiple sclerosis (MS) is widely known to be not only a chronic inflammatory disease, but also a degenerative process, but the sequence of involvement of different regions and correlation with disability is still unclear. It has become increasingly clear that MRI techniques are needed to measure aspects of pathologic changes in MS.
Objective: The aim of this study was to determine atrophy rates in RRMS patients over the course of 3 years, using voxel-based morphometry (VBM), to access T2-lesion burden (T2LV) and to investigate the relationship between these measures and neurological disability.
Methods: 25 RRMS patients (age 34.5±15.5years) underwent MRI and neurological examination in follow-up: first one - during relapse and then in 12 months after it. And 10 patients (among them) - in 36 months. Neurological deficit was measured with Expanded Disability Status score (EDSS): 4.5±2 at submission. VBM was performed to assess GM and WM volume changes in MS patients and T2LV was accessed 3 times in follow-up. Group comparisons were tested with family-wise error correction for multiple comparisons (p < 0.05). IBM SPSS Statistics 20 was also used for getting numerical data and evaluate statistically significant associations between MRI and clinical parameters.
Results: Over a period of 12 months patients experienced a decrease in the whole brain volume, total GM and WM volume (especially, corpus callosum), in right precentral and postcentral guri and in spine volume (p< 0,05). And in 36 months beside these changes MS patients showed pronounced atrophy of parahippocampal guri, left caudate and anterior lobes of cerebellum.
A strong correlation between brain and spine atrophy rates was revealed. Subcortical GM volume changes were associated with EDSS score, disease duration and correlated with neurological deficit progression, but showed no association with T2LV.
Conclusion: RRMS patients show rapid brain and spine volume loss and atrophy has distinct patterns of regional distribution. Deep GM volume is associated with disease duration and can predict neurological deterioration.
Disclosure: Nothing to disclose
Abstract: EP1451
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - Imaging
Background: Multiple sclerosis (MS) is widely known to be not only a chronic inflammatory disease, but also a degenerative process, but the sequence of involvement of different regions and correlation with disability is still unclear. It has become increasingly clear that MRI techniques are needed to measure aspects of pathologic changes in MS.
Objective: The aim of this study was to determine atrophy rates in RRMS patients over the course of 3 years, using voxel-based morphometry (VBM), to access T2-lesion burden (T2LV) and to investigate the relationship between these measures and neurological disability.
Methods: 25 RRMS patients (age 34.5±15.5years) underwent MRI and neurological examination in follow-up: first one - during relapse and then in 12 months after it. And 10 patients (among them) - in 36 months. Neurological deficit was measured with Expanded Disability Status score (EDSS): 4.5±2 at submission. VBM was performed to assess GM and WM volume changes in MS patients and T2LV was accessed 3 times in follow-up. Group comparisons were tested with family-wise error correction for multiple comparisons (p < 0.05). IBM SPSS Statistics 20 was also used for getting numerical data and evaluate statistically significant associations between MRI and clinical parameters.
Results: Over a period of 12 months patients experienced a decrease in the whole brain volume, total GM and WM volume (especially, corpus callosum), in right precentral and postcentral guri and in spine volume (p< 0,05). And in 36 months beside these changes MS patients showed pronounced atrophy of parahippocampal guri, left caudate and anterior lobes of cerebellum.
A strong correlation between brain and spine atrophy rates was revealed. Subcortical GM volume changes were associated with EDSS score, disease duration and correlated with neurological deficit progression, but showed no association with T2LV.
Conclusion: RRMS patients show rapid brain and spine volume loss and atrophy has distinct patterns of regional distribution. Deep GM volume is associated with disease duration and can predict neurological deterioration.
Disclosure: Nothing to disclose