Contributions
Abstract: EP1403
Type: ePoster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Objectives: Increased neurovascular (NV) reactivity has been shown in patients with relapsing-remitting multiple sclerosis (RRMS) during the acute exacerbation period. However, the NV reactivity after several attack is not known. We, therefore, have investigated the patients by transcranial Doppler (TCD) using simple visual stimulation during the repeated firing periods.
Patients and methods: Thirty patients (22 females and eight males, mean age 40 years) with RRMS were examined at least two times. The average TCD examination interval was 26.7 months (range 4-120 months). Mean attack number was 3.8 (range 2-8 times), average disease duration was 57 months (range 4-124 months), and average EDSS value was 2.5 (range 1-5.5). We performed transcranial Doppler recordings from the P2-segments of both posterior cerebral arteries simultaneously during simple visual stimulation. The NVC was defined as a relative increase of the blood flow velocities during visual stimulation.
Results: The NV reactivity to simple visual stimulation was significantly lower in the second test on both sides (31.5±9.2% and 29.2±7.2%; right and left side, respectively) from those of the first test (38.3±11.9% and 36.0±11.9%; right and left side, respectively) (p< 0.001).
Conclusion: Our results suggest that patients with RRMS after repeated exacerbation period have less reactive neurovascular units in the occipital cortex. The repeated demyelination and insufficient remyelination with longer disease duration may lead glial dysfunction resulting neurovascular unit impairment.
Disclosure: Nevzat Uzuner: nothing to disclose
Gülnur Tekgöl Uzuner: nothing to disclose
Abstract: EP1403
Type: ePoster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Objectives: Increased neurovascular (NV) reactivity has been shown in patients with relapsing-remitting multiple sclerosis (RRMS) during the acute exacerbation period. However, the NV reactivity after several attack is not known. We, therefore, have investigated the patients by transcranial Doppler (TCD) using simple visual stimulation during the repeated firing periods.
Patients and methods: Thirty patients (22 females and eight males, mean age 40 years) with RRMS were examined at least two times. The average TCD examination interval was 26.7 months (range 4-120 months). Mean attack number was 3.8 (range 2-8 times), average disease duration was 57 months (range 4-124 months), and average EDSS value was 2.5 (range 1-5.5). We performed transcranial Doppler recordings from the P2-segments of both posterior cerebral arteries simultaneously during simple visual stimulation. The NVC was defined as a relative increase of the blood flow velocities during visual stimulation.
Results: The NV reactivity to simple visual stimulation was significantly lower in the second test on both sides (31.5±9.2% and 29.2±7.2%; right and left side, respectively) from those of the first test (38.3±11.9% and 36.0±11.9%; right and left side, respectively) (p< 0.001).
Conclusion: Our results suggest that patients with RRMS after repeated exacerbation period have less reactive neurovascular units in the occipital cortex. The repeated demyelination and insufficient remyelination with longer disease duration may lead glial dysfunction resulting neurovascular unit impairment.
Disclosure: Nevzat Uzuner: nothing to disclose
Gülnur Tekgöl Uzuner: nothing to disclose