Abstract: EP1402
Type: ePoster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Neuromyelitis optica spectrum disorder (NMOsd) shows various brain magnetic resonance imaging (MRI) abnormalities with recurrent central nervous system (CNS) attacks, although predominantly affecting the spinal cord and optic nerve. However, it is unclear whether the clinical outcomes of NMOsd patients with CNS MRI lesions were different from those without brain MRI abnormalities.
Objectives: To investigate clinical outcomes of NMOsd patients with brain and spinal MRI abnormalities in Latin American populations.
Methods: A retrospective study from Argentina, Brazil and Venezuela that included 79 patients with NMOsd was performed. Demographic, clinical, serological status and MRI features were analyzed and compared according to different distribution patterns of brain and spinal lesions. We performed a multivariated analysis to assess the impact of different co-variable (AQP4-Ab status, gender, ethnicity, age and symptoms at onset, number of attacks, brain (localization) and spinal cord (longitudinal extensive myelitis) MRI, immunosuppressive therapy) on the final expanded disability status scale (EDSS). The differences observed between the variables were analyzed using the Fisher"s exact test.
Results: Females, white ethnicity and recurrent form predominated in all sample. No association of AQP4-ab positivity was found with gender, age at onset, ethnicity, clinical forms, disease course, brain and spinal cord MRI or long-term severe disability. We observed a trend to female on the final EDSS (p=0.09). No statistical difference was found between all co-variables and brain lesions. However, thalamus lesions were associated with low final EDSS (p < 0.02). The incidence of brain MRI abnormalities was 81.02% at the onset of disease. The cervical and thoracic spinal cord MRI lesions were 46.84% and 45.57%, respectively.
Conclusion: This study, which was conducted across different regions of Latin American, did not show association of brain and spinal MRI lesions and final EDSS. However, thalamus lesions were associated with low final EDSS. AQP4-ab was not associated with higher long-term disability.
Disclosure: nothing to disclose
Abstract: EP1402
Type: ePoster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Neuromyelitis optica spectrum disorder (NMOsd) shows various brain magnetic resonance imaging (MRI) abnormalities with recurrent central nervous system (CNS) attacks, although predominantly affecting the spinal cord and optic nerve. However, it is unclear whether the clinical outcomes of NMOsd patients with CNS MRI lesions were different from those without brain MRI abnormalities.
Objectives: To investigate clinical outcomes of NMOsd patients with brain and spinal MRI abnormalities in Latin American populations.
Methods: A retrospective study from Argentina, Brazil and Venezuela that included 79 patients with NMOsd was performed. Demographic, clinical, serological status and MRI features were analyzed and compared according to different distribution patterns of brain and spinal lesions. We performed a multivariated analysis to assess the impact of different co-variable (AQP4-Ab status, gender, ethnicity, age and symptoms at onset, number of attacks, brain (localization) and spinal cord (longitudinal extensive myelitis) MRI, immunosuppressive therapy) on the final expanded disability status scale (EDSS). The differences observed between the variables were analyzed using the Fisher"s exact test.
Results: Females, white ethnicity and recurrent form predominated in all sample. No association of AQP4-ab positivity was found with gender, age at onset, ethnicity, clinical forms, disease course, brain and spinal cord MRI or long-term severe disability. We observed a trend to female on the final EDSS (p=0.09). No statistical difference was found between all co-variables and brain lesions. However, thalamus lesions were associated with low final EDSS (p < 0.02). The incidence of brain MRI abnormalities was 81.02% at the onset of disease. The cervical and thoracic spinal cord MRI lesions were 46.84% and 45.57%, respectively.
Conclusion: This study, which was conducted across different regions of Latin American, did not show association of brain and spinal MRI lesions and final EDSS. However, thalamus lesions were associated with low final EDSS. AQP4-ab was not associated with higher long-term disability.
Disclosure: nothing to disclose