Contributions
Abstract: EP1400
Type: ePoster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) was recently developed as a concise and practical screening tool for cognitive impairment in persons with MS. It consists of three tests: Symbol Digit Modalities Test (SDMT), California Verbal Learning Test-2 (CVLT-II) and Brief Visuospatial Memory Test-Revised (BVMT-R).
A large international validation effort for the BICAMS is ongoing. We examined whether the Belgian-Dutch version of the BICAMS can differentiate PwMS and healthy controls (HC), and to what degree age, gender and level of education affect the BICAMS components.
Methods: The recommendations of The International Standards for Validation (1) were used. Wilcoxon Mann-Whitney test and Spearman rank correlation test were used appropriately.
Results: At the time of submission, data from 38 PwMS and 42 HC are reported. BVMT was significantly (p< 0.05) lower in PwMS (23, +/-9) than in controls (30.1, +/-4.1). SDMT was significantly (p< 0.05) lower in PwMS (49.2, +/-14.2) than in controls (64.5, +/-9.7).
In this interim analysis, there was no significant difference for the CVLT.
The inter-test correlation for PwMS was 0.71 between BVMT and SDMT, 0.58 between BVMT and CVLT and 0.66 between CVLT and SDMT. For HC no correlation was found between BVMT and CVLT (R=-0.05), and a small correlation between BVMT and SDMT (R=0.33) and CVLT and SDMT (R=0.33).
Age was negatively, and level of education positively, correlated with BVMT, CVLT and SDMT for PwMS, but not for controls
Conclusions: BVMT and SDMT scores were significantly lower in PwMS. The SDMT is most sensitive at distinguishing both groups. Age and education level influenced all components of the BICAMS.
Inclusion is ongoing to reach 100 PwMS and 100 controls in both the Belgian Dutch and Belgian French groups.
Keywords: Multiple Sclerosis, cognition, cognitive dysfunction, neuropsychological tests/screening.
References: (1): Brief International Cognitive Assessment for MS (BICAMS): international standards for validation
Benedict Ralph HB et al. BMC Neurology 2012, 12:55
Disclosure: nothing to disclose
Abstract: EP1400
Type: ePoster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) was recently developed as a concise and practical screening tool for cognitive impairment in persons with MS. It consists of three tests: Symbol Digit Modalities Test (SDMT), California Verbal Learning Test-2 (CVLT-II) and Brief Visuospatial Memory Test-Revised (BVMT-R).
A large international validation effort for the BICAMS is ongoing. We examined whether the Belgian-Dutch version of the BICAMS can differentiate PwMS and healthy controls (HC), and to what degree age, gender and level of education affect the BICAMS components.
Methods: The recommendations of The International Standards for Validation (1) were used. Wilcoxon Mann-Whitney test and Spearman rank correlation test were used appropriately.
Results: At the time of submission, data from 38 PwMS and 42 HC are reported. BVMT was significantly (p< 0.05) lower in PwMS (23, +/-9) than in controls (30.1, +/-4.1). SDMT was significantly (p< 0.05) lower in PwMS (49.2, +/-14.2) than in controls (64.5, +/-9.7).
In this interim analysis, there was no significant difference for the CVLT.
The inter-test correlation for PwMS was 0.71 between BVMT and SDMT, 0.58 between BVMT and CVLT and 0.66 between CVLT and SDMT. For HC no correlation was found between BVMT and CVLT (R=-0.05), and a small correlation between BVMT and SDMT (R=0.33) and CVLT and SDMT (R=0.33).
Age was negatively, and level of education positively, correlated with BVMT, CVLT and SDMT for PwMS, but not for controls
Conclusions: BVMT and SDMT scores were significantly lower in PwMS. The SDMT is most sensitive at distinguishing both groups. Age and education level influenced all components of the BICAMS.
Inclusion is ongoing to reach 100 PwMS and 100 controls in both the Belgian Dutch and Belgian French groups.
Keywords: Multiple Sclerosis, cognition, cognitive dysfunction, neuropsychological tests/screening.
References: (1): Brief International Cognitive Assessment for MS (BICAMS): international standards for validation
Benedict Ralph HB et al. BMC Neurology 2012, 12:55
Disclosure: nothing to disclose