Contributions
Abstract: EP1397
Type: ePoster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Introduction: The positivity of ANA has found as 22-36% in relapsing-remitting multiple sclerosis and as 30% in chronic progressive multiple sclerosis, and anti-SSA and anti-SSB were found positive with a 2-17% frequency and anti-phospholipid antibody with a 32.6-55% rate.
Materials and methods: One hundred thirty-two patients who were evaluated between October 2010 and September 2013 and were diagnosed with RRMS, SPMS and CIS according to McDonald 2005 criteria, and 45 health controls with similiar demographic features were examined. At the time of referral, ANA, anti-DNA, anti-SSA anti-SSB, p and c- ANCA, anticardiolipin and anti-phosphatide serine IgM and IgG were studied in all cases. The relationships between the positivity of autoantibodies and age, gender, clinical presentation, EDSS, the localization and number of demyelinating plaque in brain and spinal magnetic resonance imaging, oligoclonal band positivity and elevation of IgG index in CSF and evoked-potentials abnormality were investigated.
Results: It was detected a significant difference for only ANA positivity in MS and CIS cases compared to health control groups. It was found a significant relationship between ANA and anti-cardiolipin antibody positivity and female gender, and relationship between location of demyelinating plaques in periventricular and subcortical white matter in cranial MRI and OCB positivity in CSF (p< 0.05).
Discussion: In the studies, any significant relationship was found between the positivity of autoantibodies and age, duration of disease, type of disease and disability. The positivity of autoantibodies in MS was explained as signs of an increased tendency toward autoimmunity and ongoing immune disease.
Disclosure: nothing to disclosure
Abstract: EP1397
Type: ePoster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Introduction: The positivity of ANA has found as 22-36% in relapsing-remitting multiple sclerosis and as 30% in chronic progressive multiple sclerosis, and anti-SSA and anti-SSB were found positive with a 2-17% frequency and anti-phospholipid antibody with a 32.6-55% rate.
Materials and methods: One hundred thirty-two patients who were evaluated between October 2010 and September 2013 and were diagnosed with RRMS, SPMS and CIS according to McDonald 2005 criteria, and 45 health controls with similiar demographic features were examined. At the time of referral, ANA, anti-DNA, anti-SSA anti-SSB, p and c- ANCA, anticardiolipin and anti-phosphatide serine IgM and IgG were studied in all cases. The relationships between the positivity of autoantibodies and age, gender, clinical presentation, EDSS, the localization and number of demyelinating plaque in brain and spinal magnetic resonance imaging, oligoclonal band positivity and elevation of IgG index in CSF and evoked-potentials abnormality were investigated.
Results: It was detected a significant difference for only ANA positivity in MS and CIS cases compared to health control groups. It was found a significant relationship between ANA and anti-cardiolipin antibody positivity and female gender, and relationship between location of demyelinating plaques in periventricular and subcortical white matter in cranial MRI and OCB positivity in CSF (p< 0.05).
Discussion: In the studies, any significant relationship was found between the positivity of autoantibodies and age, duration of disease, type of disease and disability. The positivity of autoantibodies in MS was explained as signs of an increased tendency toward autoimmunity and ongoing immune disease.
Disclosure: nothing to disclosure