Contributions
Abstract: EP1392
Type: ePoster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Cognitive impairment occurs in 40-65% of multiple sclerosis (MS) patients, it is mostly results in information processing speed, attention, memory loss and executive functions. Pathological processes occurring in MS lead to irreversible brain damage resulting in brain atrophy.
Objectives: To investigate the correlations between cognitive impairment, duration of disease and brain atrophy in subjects with relapsing-remitting multiple sclerosis (RRMS) treated with interferons beta.
Methods: Brief Visuospatial Memory Test -Revised(BVMT-R), BVMTR-D (Brief Visuospatial Memory Test Revised- Delayed; SRT (Selective Reminding Test),STR-D (Selective Reminding Test -Delayed); PASAT(Paced Auditory Serial Addition Test), SDMT(Symbol Digit Modalities Test) and MRI (Magnetic Resonance Imaging) was administered in all subjects. MRI included:Segmented Brain Volume(BrainSegVol);Total Gray Matter Volume (TotalGrayVol); Estimated Total Intracranial Volume (EstimatedTotalIntraCranialVol);Cortex volume and SupraTentorial- Supratentorial Structures Volume. Statistical analysis was performed using Spearman´s rank correlation test. P< 0.05 was considered as statistically significant.
Results: We included 32 subjects with RRMS, 24 woman, 8 men. Mean age 32,4 years (SD=6.9), mean EDSS (Expanded Disability Status Scale) 2.3 (SD=0,8), mean duration of disease 12.5 months (SD=21.4). Cognition tests and MRI were performed before taking first dose of interferons. All subjects were previously treatment naive. Significant correlations was found between duration of disease and STR score (p< 0.05), Spearman"s correlation coefficient(SCC):-0.2859 p=0.04414. Correlation between BrainSegVol, TotalGrayVol, Cortex volume and STR score were also positive p< 0.05. For BrainSegVol and STR:SCC:0.3601988,p=0.04286. For TotalGrayVol and STR: SCC:0.3826,p=0.0307. For Cortex and STR:SCC:0.3538,p=0.04699. Another statistical finding was correlation between subject"s education and PASAT score: SCC:0.2848, p=0.04504. No statistically significant relations were found between SDMT, STR-D,PASAT and volumetric MRI parameters. No statistically correlations were found between SDMT, STR-D, PASAT score and MS duration.
Conclusions: Cognitive impairment may depend on disease duration and subject"s education. Our results suggest that disturbances in learning and verbal memory may reflect brain atrophy in early MS.
Disclosure: Nothing to disclosure
Abstract: EP1392
Type: ePoster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Cognitive impairment occurs in 40-65% of multiple sclerosis (MS) patients, it is mostly results in information processing speed, attention, memory loss and executive functions. Pathological processes occurring in MS lead to irreversible brain damage resulting in brain atrophy.
Objectives: To investigate the correlations between cognitive impairment, duration of disease and brain atrophy in subjects with relapsing-remitting multiple sclerosis (RRMS) treated with interferons beta.
Methods: Brief Visuospatial Memory Test -Revised(BVMT-R), BVMTR-D (Brief Visuospatial Memory Test Revised- Delayed; SRT (Selective Reminding Test),STR-D (Selective Reminding Test -Delayed); PASAT(Paced Auditory Serial Addition Test), SDMT(Symbol Digit Modalities Test) and MRI (Magnetic Resonance Imaging) was administered in all subjects. MRI included:Segmented Brain Volume(BrainSegVol);Total Gray Matter Volume (TotalGrayVol); Estimated Total Intracranial Volume (EstimatedTotalIntraCranialVol);Cortex volume and SupraTentorial- Supratentorial Structures Volume. Statistical analysis was performed using Spearman´s rank correlation test. P< 0.05 was considered as statistically significant.
Results: We included 32 subjects with RRMS, 24 woman, 8 men. Mean age 32,4 years (SD=6.9), mean EDSS (Expanded Disability Status Scale) 2.3 (SD=0,8), mean duration of disease 12.5 months (SD=21.4). Cognition tests and MRI were performed before taking first dose of interferons. All subjects were previously treatment naive. Significant correlations was found between duration of disease and STR score (p< 0.05), Spearman"s correlation coefficient(SCC):-0.2859 p=0.04414. Correlation between BrainSegVol, TotalGrayVol, Cortex volume and STR score were also positive p< 0.05. For BrainSegVol and STR:SCC:0.3601988,p=0.04286. For TotalGrayVol and STR: SCC:0.3826,p=0.0307. For Cortex and STR:SCC:0.3538,p=0.04699. Another statistical finding was correlation between subject"s education and PASAT score: SCC:0.2848, p=0.04504. No statistically significant relations were found between SDMT, STR-D,PASAT and volumetric MRI parameters. No statistically correlations were found between SDMT, STR-D, PASAT score and MS duration.
Conclusions: Cognitive impairment may depend on disease duration and subject"s education. Our results suggest that disturbances in learning and verbal memory may reflect brain atrophy in early MS.
Disclosure: Nothing to disclosure