Contributions
Abstract: EP1384
Type: ePoster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: The aim of this study was to investigate weather autonomic dysfunction calculated in the form of the Composite Autonomic Scoring Scale (CASS) has clinical consequences in patients with early MS. This was assessed by comparing differences in average supine and standing heart rate (HR), systolic blood pressure (sBP) and diastolic BP (dBP) in patients with different forms of autonomic dysfunction.
Methods: This prospective, cohort study included 104 consecutive early MS patients. Quantitative Sudomotor Axon Reflex Test (QSART), heart rate and blood pressure responses to Valsalva maneuver, heart rate response to deep breathing and blood pressure response to passive tilt were performed. The results were interpreted in the form of CASS. Average HR, sBP and dBP were calculated in the supine and standing positions.
Results: CASS ≥1 was present in 59.8%, adrenergic index ≥1 in 42.6%, cardiovagal index ≥1 in 5.0%, and sudomotor index ≥1 in 32.6% patients. Patients with adrenergic index ≥1 had significantly higher standing HR compared to patients with adrenergic index 0 (96±13.5 and 90±12, respectively, p=0.032). The same trend was seen for supine HR, however with borderline significance (74±11 and 70±10, respectively, p=0.057). There was no difference in sBP and dBP for both positions regarding adrenergic index (p>0.05). There were no differences in HR, sBP or dBP in relation to cardiovagal or sudomotor indices or CASS (p>0.05).
Conclusion: These findings could be explained with lower-than-normal sympathetic output in selected patients, meaning that these patients need higher HR to compensate decrease in BP upon passive tilt.
Disclosure: Funding: Croatian Science Foundation grant HRZZ UIP-11-2013-2622
Abstract: EP1384
Type: ePoster
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: The aim of this study was to investigate weather autonomic dysfunction calculated in the form of the Composite Autonomic Scoring Scale (CASS) has clinical consequences in patients with early MS. This was assessed by comparing differences in average supine and standing heart rate (HR), systolic blood pressure (sBP) and diastolic BP (dBP) in patients with different forms of autonomic dysfunction.
Methods: This prospective, cohort study included 104 consecutive early MS patients. Quantitative Sudomotor Axon Reflex Test (QSART), heart rate and blood pressure responses to Valsalva maneuver, heart rate response to deep breathing and blood pressure response to passive tilt were performed. The results were interpreted in the form of CASS. Average HR, sBP and dBP were calculated in the supine and standing positions.
Results: CASS ≥1 was present in 59.8%, adrenergic index ≥1 in 42.6%, cardiovagal index ≥1 in 5.0%, and sudomotor index ≥1 in 32.6% patients. Patients with adrenergic index ≥1 had significantly higher standing HR compared to patients with adrenergic index 0 (96±13.5 and 90±12, respectively, p=0.032). The same trend was seen for supine HR, however with borderline significance (74±11 and 70±10, respectively, p=0.057). There was no difference in sBP and dBP for both positions regarding adrenergic index (p>0.05). There were no differences in HR, sBP or dBP in relation to cardiovagal or sudomotor indices or CASS (p>0.05).
Conclusion: These findings could be explained with lower-than-normal sympathetic output in selected patients, meaning that these patients need higher HR to compensate decrease in BP upon passive tilt.
Disclosure: Funding: Croatian Science Foundation grant HRZZ UIP-11-2013-2622