Contributions
Abstract: EP1382
Type: ePoster
Abstract Category: Clinical aspects of MS - MS symptoms
Background and goals: Mental Disorders(MDs) constitute a major and early co-morbidity in patients with Multiple Sclerosis(MS). The aim of this cross-sectional study was to examine the prevalence of MDs in MS patients and their putative repercussions on cognition.
Methods: Our sample consisted of 257 MS patients (65.4% women, mean age 43.1±11.4, mean disease duration 146.9±106.6 months), 70.4% with relapsing-remitting MS and 73.2% on disease modifying therapy. Measurements (or Evaluation) included: M.I.N.I International Neuropsychiatric Interview, Mini-Mental-State-Examination Test(MMSE), Clock-Drawing Test(CDT), Trail-Making Test(TMT), Stroop Test, Wechsler-Intelligence Scale(WIS), Rey-Auditory-Verbal Test(RAVT), Rey-Complex-Figure Test(RCFT), Winsconsin-Card-Sorting Test(WCST) and Babcock-Story-Recall Test(BSRT).
Results: 36.6% of the patients were identified with one MD, while 18.7% and 5.1% with two or three MDs, respectively. Among patients with one MD, generalized anxiety disorder(GAD) was the commonest(53.2%), followed by dysthymia(27.7%) and one major depressive episode(MDE)(8.5%). Among those with two or more MDs, the commonest psychiatric co-morbidities were MDE-GAD(18 patients), dysthymia-GAD(18 patients) and dysthymia-GAD-panic disorder(4 patients). Older patients were significantly more likely to present with two or more MDs than one or no MD. Females and less educated patients showed a tendency towards more MD suffering, although this was not significant. Regarding cognition, patients with one or more MDs showed statistically significant difficulties in BSRT-Immediate Recall Test (p=0.05) and WIS-Visual Memory (p=0.04) compared to patients with no MD. Patients with two or more MDs scored significantly less in MMSE and RCF Test than those with one MD. Conclusions: Compared to other published studies, our results showed higher prevalence of MDs (total 60.4%), mostly stress-related, among patients with MS, which could be presumably attributed to the institutional health reforms and the chronic economic stress during the last six years of the Greek economical crisis. Finally, the presence of one or more MD was most potently associated with memory problems in MS patients.
Disclosure: Ilia Theotoka: nothing to disclose
Serafeim Katsavos: nothing to disclose
Maria Gontika: nothing to disclose
Artemios Artemiadis: nothing to disclose
Foteini Christidi: nothing to disclose
Paraskevi Argyrou: nothing to disclose
Markos Zacharis: nothing to disclose
Ioannis Zalonis: nothing to disclose
Thomas Paparrigopoulos: nothing to disclose
Maria Anagnostouli: nothing to disclose
Abstract: EP1382
Type: ePoster
Abstract Category: Clinical aspects of MS - MS symptoms
Background and goals: Mental Disorders(MDs) constitute a major and early co-morbidity in patients with Multiple Sclerosis(MS). The aim of this cross-sectional study was to examine the prevalence of MDs in MS patients and their putative repercussions on cognition.
Methods: Our sample consisted of 257 MS patients (65.4% women, mean age 43.1±11.4, mean disease duration 146.9±106.6 months), 70.4% with relapsing-remitting MS and 73.2% on disease modifying therapy. Measurements (or Evaluation) included: M.I.N.I International Neuropsychiatric Interview, Mini-Mental-State-Examination Test(MMSE), Clock-Drawing Test(CDT), Trail-Making Test(TMT), Stroop Test, Wechsler-Intelligence Scale(WIS), Rey-Auditory-Verbal Test(RAVT), Rey-Complex-Figure Test(RCFT), Winsconsin-Card-Sorting Test(WCST) and Babcock-Story-Recall Test(BSRT).
Results: 36.6% of the patients were identified with one MD, while 18.7% and 5.1% with two or three MDs, respectively. Among patients with one MD, generalized anxiety disorder(GAD) was the commonest(53.2%), followed by dysthymia(27.7%) and one major depressive episode(MDE)(8.5%). Among those with two or more MDs, the commonest psychiatric co-morbidities were MDE-GAD(18 patients), dysthymia-GAD(18 patients) and dysthymia-GAD-panic disorder(4 patients). Older patients were significantly more likely to present with two or more MDs than one or no MD. Females and less educated patients showed a tendency towards more MD suffering, although this was not significant. Regarding cognition, patients with one or more MDs showed statistically significant difficulties in BSRT-Immediate Recall Test (p=0.05) and WIS-Visual Memory (p=0.04) compared to patients with no MD. Patients with two or more MDs scored significantly less in MMSE and RCF Test than those with one MD. Conclusions: Compared to other published studies, our results showed higher prevalence of MDs (total 60.4%), mostly stress-related, among patients with MS, which could be presumably attributed to the institutional health reforms and the chronic economic stress during the last six years of the Greek economical crisis. Finally, the presence of one or more MD was most potently associated with memory problems in MS patients.
Disclosure: Ilia Theotoka: nothing to disclose
Serafeim Katsavos: nothing to disclose
Maria Gontika: nothing to disclose
Artemios Artemiadis: nothing to disclose
Foteini Christidi: nothing to disclose
Paraskevi Argyrou: nothing to disclose
Markos Zacharis: nothing to disclose
Ioannis Zalonis: nothing to disclose
Thomas Paparrigopoulos: nothing to disclose
Maria Anagnostouli: nothing to disclose