Contributions
Abstract: EP1379
Type: ePoster
Abstract Category: Clinical aspects of MS - MS symptoms
Introduction: Fatigue is an underestimated symptom affecting up to 95% of patients with multiple sclerosis (MS). It exacerbates impairment and affects patients" sense of control over the illness and overall mental health. The study aims to assess the association between fatigue and cognitive dysfunction, physical disability, and quality of life in MS patients.
Methods: Adult MS patients diagnosed as relapsing remitting (RRMS) or progressive according to McDonald"s criteria were recruited between Aug-15 and Jan-16. The Modified Fatigue Impact Scale (MFIS) was administered to both MS and healthy age-and-sex-matched control subjects (score ≥38= fatigued). Quality of life was assessed using the Multiple Sclerosis International Quality of Life questionnaire (MuSIQoL) and processing speed via the Symbol Digit Modality Test (SDMT). Univariate analysis was performed to explore differences between subjects with and without fatigue. Multivariate analysis controlling for age, gender, education level, EDSS, disease duration, clinical depression, and MS type and treatment was performed to examine the correlations between fatigue and different variables.
Results: 113 MS patients (28% males, 80.9% RRMS) with mean (SD) disease duration of 8.6 (8.2) years and 57 healthy subjects were enrolled. Significant fatigue was seen in 32.3% of MS patients and 6.2% in controls. Among fatigued MS participants, 66% and 75% had respective physical and cognitive fatigue. Multivariate analysis showed a negative association between SDMT and fatigue (P=0.001, OR=0.88), more specifically with its cognitive domain (p= 0.003, OR=0.9). There was a positive association between fatigue and EDSS (P=0.04, OR=1.4), particularly with pyramidal FS score (p=0.031, OR=2.5).
Conclusion: Physical and cognitive are the most affected fatigue domains in MS patients. There is an association between cognitive fatigue and SDMT, and physical fatigue with both EDSS pyramidal FS score and quality of life. These findings allow us to assist patients in coping with this disabling but treatable aspect of MS
Disclosure:
Marianne Said: Nothing to disclose
Nabil Al Ayoubi: Nothing to disclose
Anthony Msan: Nothing to disclose
Joelle Alam: Nothing to disclose
Stephanie Ghassan: Nothing to disclose
Hala Darwish: Nothing to disclose
Samia Khoury: Nothing to disclose
Abstract: EP1379
Type: ePoster
Abstract Category: Clinical aspects of MS - MS symptoms
Introduction: Fatigue is an underestimated symptom affecting up to 95% of patients with multiple sclerosis (MS). It exacerbates impairment and affects patients" sense of control over the illness and overall mental health. The study aims to assess the association between fatigue and cognitive dysfunction, physical disability, and quality of life in MS patients.
Methods: Adult MS patients diagnosed as relapsing remitting (RRMS) or progressive according to McDonald"s criteria were recruited between Aug-15 and Jan-16. The Modified Fatigue Impact Scale (MFIS) was administered to both MS and healthy age-and-sex-matched control subjects (score ≥38= fatigued). Quality of life was assessed using the Multiple Sclerosis International Quality of Life questionnaire (MuSIQoL) and processing speed via the Symbol Digit Modality Test (SDMT). Univariate analysis was performed to explore differences between subjects with and without fatigue. Multivariate analysis controlling for age, gender, education level, EDSS, disease duration, clinical depression, and MS type and treatment was performed to examine the correlations between fatigue and different variables.
Results: 113 MS patients (28% males, 80.9% RRMS) with mean (SD) disease duration of 8.6 (8.2) years and 57 healthy subjects were enrolled. Significant fatigue was seen in 32.3% of MS patients and 6.2% in controls. Among fatigued MS participants, 66% and 75% had respective physical and cognitive fatigue. Multivariate analysis showed a negative association between SDMT and fatigue (P=0.001, OR=0.88), more specifically with its cognitive domain (p= 0.003, OR=0.9). There was a positive association between fatigue and EDSS (P=0.04, OR=1.4), particularly with pyramidal FS score (p=0.031, OR=2.5).
Conclusion: Physical and cognitive are the most affected fatigue domains in MS patients. There is an association between cognitive fatigue and SDMT, and physical fatigue with both EDSS pyramidal FS score and quality of life. These findings allow us to assist patients in coping with this disabling but treatable aspect of MS
Disclosure:
Marianne Said: Nothing to disclose
Nabil Al Ayoubi: Nothing to disclose
Anthony Msan: Nothing to disclose
Joelle Alam: Nothing to disclose
Stephanie Ghassan: Nothing to disclose
Hala Darwish: Nothing to disclose
Samia Khoury: Nothing to disclose