Contributions
Abstract: EP1376
Type: ePoster
Abstract Category: Clinical aspects of MS - MS and gender
Background: Risk of postpartum relapses in the first three months is higher then baseline risk. Factors such as hormonal variances have been suggested. We sought to see if there was a correlation between Vitamin D levels and risk of relapses.
Methods: A retrospective review was performed at our tertiary outpatient MS Center to identify patients who had given birth in the last 5 years. 33 pregnant or post-partum patients with a diagnosis of Multiple Sclerosis were identified. Average age, duration of disease, reinitiation of medication and breastfeeding incidence were collected
Vitamin D levels of these women were analyzed prior to delivery, 1 to 3 months postpartum, and >3 months post-partum.
Results: Of the 23 patient serum Vitamin D levels collected prior delivery 10 patients had low Vitamin D levels, while the remaining 13 patients fell within normal limits (WNL) (ml). Of the 10 patients with low recorded serum Vitamin D levels prior to pregnancy/while pregnant, 2 of the 10 patients experienced a relapse 4 to 6 weeks post-partum.
In 21 patients with postpartum vitamin D serum results, 7 recorded low Vitamin D serum levels, whereas the remaining 14 patients fall WNL. Of the 7 patients with low levels 1 to 3 month"s post-partum, 2 experienced a relapse 2 to 4 weeks post-partum. However, 2 patients who recorded WNL vitamin D levels also experienced a relapse. Vitamin D levels were not seen to have an effect on relapse protection.
Follow up serum Vitamin D levels were tested on a total of 17 out of the 33 patients during 5 to 26 months post-partum. Of the 17 patients with a recorded serum Vitamin D level, 6 patients had recorded low levels, whereas the remaining 11 fall WNL. Of the 6 patients who recorded low vitamin D levels, 2 experienced a relapse.
Of the 21 patients with postpartum vitamin d serum results, 7 recorded low Vitamin D serum levels, whereas the remaining 14 patients fall were normal. Of the 7 patients with low levels 1 to 3 month"s post-partum, 2 experienced a relapse 2 to 4 weeks post-partum. However, 2 patients who recorded WNL vitamin D levels also experienced a relapse.
Post-partum MRI changes were also examined. Parameters used in modern day trials were used. Of the 33 patients screened, 6 patients experienced changes in their MRI.
Conclusion: Vitamin D levels were not seen to have an effect on relapse protection. However a larger sample size may show a more statistical correlation.
Disclosure: There are no potential conflicts of interest as this study was not funded.
Abstract: EP1376
Type: ePoster
Abstract Category: Clinical aspects of MS - MS and gender
Background: Risk of postpartum relapses in the first three months is higher then baseline risk. Factors such as hormonal variances have been suggested. We sought to see if there was a correlation between Vitamin D levels and risk of relapses.
Methods: A retrospective review was performed at our tertiary outpatient MS Center to identify patients who had given birth in the last 5 years. 33 pregnant or post-partum patients with a diagnosis of Multiple Sclerosis were identified. Average age, duration of disease, reinitiation of medication and breastfeeding incidence were collected
Vitamin D levels of these women were analyzed prior to delivery, 1 to 3 months postpartum, and >3 months post-partum.
Results: Of the 23 patient serum Vitamin D levels collected prior delivery 10 patients had low Vitamin D levels, while the remaining 13 patients fell within normal limits (WNL) (ml). Of the 10 patients with low recorded serum Vitamin D levels prior to pregnancy/while pregnant, 2 of the 10 patients experienced a relapse 4 to 6 weeks post-partum.
In 21 patients with postpartum vitamin D serum results, 7 recorded low Vitamin D serum levels, whereas the remaining 14 patients fall WNL. Of the 7 patients with low levels 1 to 3 month"s post-partum, 2 experienced a relapse 2 to 4 weeks post-partum. However, 2 patients who recorded WNL vitamin D levels also experienced a relapse. Vitamin D levels were not seen to have an effect on relapse protection.
Follow up serum Vitamin D levels were tested on a total of 17 out of the 33 patients during 5 to 26 months post-partum. Of the 17 patients with a recorded serum Vitamin D level, 6 patients had recorded low levels, whereas the remaining 11 fall WNL. Of the 6 patients who recorded low vitamin D levels, 2 experienced a relapse.
Of the 21 patients with postpartum vitamin d serum results, 7 recorded low Vitamin D serum levels, whereas the remaining 14 patients fall were normal. Of the 7 patients with low levels 1 to 3 month"s post-partum, 2 experienced a relapse 2 to 4 weeks post-partum. However, 2 patients who recorded WNL vitamin D levels also experienced a relapse.
Post-partum MRI changes were also examined. Parameters used in modern day trials were used. Of the 33 patients screened, 6 patients experienced changes in their MRI.
Conclusion: Vitamin D levels were not seen to have an effect on relapse protection. However a larger sample size may show a more statistical correlation.
Disclosure: There are no potential conflicts of interest as this study was not funded.