Contributions
Abstract: EP1372
Type: ePoster
Abstract Category: Clinical aspects of MS - Epidemiology
Background/goals: In the general population, associations have been observed between stressful life events (SLE) and depression and anxiety. Five years post diagnosis of a first clinical diagnosis of central nervous system demyelination, we examined various measures of SLE and symptoms implicated in the disease which include depression, anxiety and fatigue.
Methods: The sample comprised of a prospective cohort with 236 participants who had a first clinical diagnosis of central nervous system demyelination. Depression and anxiety (HADS, 0-21) and fatigue (Fatigue Severity Scale, 0-7) were assessed at the five-year review. SLEs were assessed at yearly intervals for five years using a modified questionnaire based on the Social Readjustment Rating Scale by Holmes & Rahe.
Results: We found that negative, but not positive, SLE number was associated with anxiety, depression, and fatigue at five years (for example: total SLE number over 5 years β =0.20, 95%CI=0.04, 0.37, p=0.01 for depression, β =0.40, 95%CI=0.22, 0.58, p< 0.001 for anxiety, β =0.09, 95%CI=0.03, 0.14, p=0.01 for fatigue). An increased duration (months) of negative SLE over five years was significantly associated with anxiety and depression (for example: β =0.07, 95%CI=0.01, 0.13, p=0.03 for depression and β =0.10, 95%CI=0.03, 0.17, p< 0.001 for anxiety) but not fatigue (p>0.1). Similarly, perceived severity over five years was significantly associated with anxiety and depression but not fatigue.
Conclusion: Negative SLE but not positive SLE significantly predicted other MS symptoms depression, anxiety and fatigue. We found that negative SLE may impact differently on fatigue when compared to depression and anxiety, which will impact the structure of future stress management intervention programs.
Disclosure: Authors have no relevant disclosures
Abstract: EP1372
Type: ePoster
Abstract Category: Clinical aspects of MS - Epidemiology
Background/goals: In the general population, associations have been observed between stressful life events (SLE) and depression and anxiety. Five years post diagnosis of a first clinical diagnosis of central nervous system demyelination, we examined various measures of SLE and symptoms implicated in the disease which include depression, anxiety and fatigue.
Methods: The sample comprised of a prospective cohort with 236 participants who had a first clinical diagnosis of central nervous system demyelination. Depression and anxiety (HADS, 0-21) and fatigue (Fatigue Severity Scale, 0-7) were assessed at the five-year review. SLEs were assessed at yearly intervals for five years using a modified questionnaire based on the Social Readjustment Rating Scale by Holmes & Rahe.
Results: We found that negative, but not positive, SLE number was associated with anxiety, depression, and fatigue at five years (for example: total SLE number over 5 years β =0.20, 95%CI=0.04, 0.37, p=0.01 for depression, β =0.40, 95%CI=0.22, 0.58, p< 0.001 for anxiety, β =0.09, 95%CI=0.03, 0.14, p=0.01 for fatigue). An increased duration (months) of negative SLE over five years was significantly associated with anxiety and depression (for example: β =0.07, 95%CI=0.01, 0.13, p=0.03 for depression and β =0.10, 95%CI=0.03, 0.17, p< 0.001 for anxiety) but not fatigue (p>0.1). Similarly, perceived severity over five years was significantly associated with anxiety and depression but not fatigue.
Conclusion: Negative SLE but not positive SLE significantly predicted other MS symptoms depression, anxiety and fatigue. We found that negative SLE may impact differently on fatigue when compared to depression and anxiety, which will impact the structure of future stress management intervention programs.
Disclosure: Authors have no relevant disclosures