Contributions
Abstract: EP1365
Type: ePoster
Abstract Category: Clinical aspects of MS - Epidemiology
Introduction: Age adjusted prevalence of MS has been shown to increase with degrees of latitude from the equator. Case data from the last 5 years (2010-15) from the Scottish MS Register (SMSR) was analysed to see if MS Incidence in Scotland showed a similar trend. Individual cases were linked to small area data (datazones) from the Scottish Index of Multiple Deprivation 2012 data (SIMD)
Methods: All cases from the SMSR with a diagnosis date between 2010-15 were analysed. Each case was linked to a datazone from SIMD giving co-ordinates of latitude and longitude for each case. Latitudes were converted from degrees, minutes and seconds into a decimal range. The range of latitude was split into groupings of one degree difference and the total number of MS cases and total background population for each latitude grouping was calculated. Incidence rates per 100,000/year were then calculated for each group. An ANOVA analysis of variance was carried out to test for statistical significance of the differences. Statistical significance was taken as p< 0.05.
Results: 6505 datazones were identified. Datazone latitude ranged from 54.69006 (54d 41m 24s N) to 60.7187133 (60d 43m 7s N). Datazones were grouped by latitude into six groups by latitude banding. Overall 2536 MS cases were identified, the range for the six groupings was 14-1717 MS cases. Population per datazone ranged from 0 - 7524 (Mean = 803). MS Incidence (per 100,000 per year) for the groups ranged from 9.9 to 20.5 (mean = 13.2). One-way ANOVA showed a significant difference between groups (p < 0.005)
Conclusion: There is a significant difference between MS Incidence (cases/100,000/yr) rates between latitude bands. MS Incidence tends to increase with latitude. The highest peak of MS Incidence appears to be overlying south Orkney.
Disclosure: Dr James McDonald; Nothing to disclose
Ms Hazel Dodds: Nothing to disclose
Mr Martin O´Neill: Nothing to disclose
Dr Belinda Weller: Nothing to disclose
Dr Jonathan O´Riordan: I have been principal Investigator in trials sponsored by Biogen, GW Pharma, Novartis, Genzyme (a Sanofi company), Teva and Bayer. I have been a guest of Novartis, Biogen and Teva to attend various meetings and conferences. I have acted as consultant in advisory boards arranged by Biogen, Novartis and Genzyme (a Sanofi company). I hold shares < £10,000 in GW Pharma.
Abstract: EP1365
Type: ePoster
Abstract Category: Clinical aspects of MS - Epidemiology
Introduction: Age adjusted prevalence of MS has been shown to increase with degrees of latitude from the equator. Case data from the last 5 years (2010-15) from the Scottish MS Register (SMSR) was analysed to see if MS Incidence in Scotland showed a similar trend. Individual cases were linked to small area data (datazones) from the Scottish Index of Multiple Deprivation 2012 data (SIMD)
Methods: All cases from the SMSR with a diagnosis date between 2010-15 were analysed. Each case was linked to a datazone from SIMD giving co-ordinates of latitude and longitude for each case. Latitudes were converted from degrees, minutes and seconds into a decimal range. The range of latitude was split into groupings of one degree difference and the total number of MS cases and total background population for each latitude grouping was calculated. Incidence rates per 100,000/year were then calculated for each group. An ANOVA analysis of variance was carried out to test for statistical significance of the differences. Statistical significance was taken as p< 0.05.
Results: 6505 datazones were identified. Datazone latitude ranged from 54.69006 (54d 41m 24s N) to 60.7187133 (60d 43m 7s N). Datazones were grouped by latitude into six groups by latitude banding. Overall 2536 MS cases were identified, the range for the six groupings was 14-1717 MS cases. Population per datazone ranged from 0 - 7524 (Mean = 803). MS Incidence (per 100,000 per year) for the groups ranged from 9.9 to 20.5 (mean = 13.2). One-way ANOVA showed a significant difference between groups (p < 0.005)
Conclusion: There is a significant difference between MS Incidence (cases/100,000/yr) rates between latitude bands. MS Incidence tends to increase with latitude. The highest peak of MS Incidence appears to be overlying south Orkney.
Disclosure: Dr James McDonald; Nothing to disclose
Ms Hazel Dodds: Nothing to disclose
Mr Martin O´Neill: Nothing to disclose
Dr Belinda Weller: Nothing to disclose
Dr Jonathan O´Riordan: I have been principal Investigator in trials sponsored by Biogen, GW Pharma, Novartis, Genzyme (a Sanofi company), Teva and Bayer. I have been a guest of Novartis, Biogen and Teva to attend various meetings and conferences. I have acted as consultant in advisory boards arranged by Biogen, Novartis and Genzyme (a Sanofi company). I hold shares < £10,000 in GW Pharma.