Contributions
Abstract: EP1363
Type: ePoster
Abstract Category: Clinical aspects of MS - Epidemiology
Introduction: Multiple sclerosis (MS) not only causes somatic disability but often leads to psychopathological symptoms. Of these symptoms, cognitive impairment (CIm) can appear at any age and any stage of the disease. The impact of CIm on the patients" quality of life (QoL) was assessed by only a small number of evaluations. Benedict et al showed that CIm, depression and fatigue worsen the patients" QoL as much as the physical impairment. This study aimed to assess the impact of CIm on the patients´ QoL and the possible difference between genders and different levels of education.
Patients and methods: We recruited 482 patients suffering from relapsing-remitting MS or clinically isolated syndrome treated at the Department of Neurology of the University of Szeged, the Jahn Ferenc Teaching Hospital of Budapest and the Markhot Ferenc Teaching Hospital of Eger into our study. All patients were in remission for at least 30 days. We used the BICAMS battery for the assessment of their cognitive state while we administered the MSQoL-54 battery for the evaluation of their QoL. We used one-way ANOVA to assess the differences in the scores of MSQoL-54 gear to cognitive impairment, gender and education.
Results: Of the recruited 482 patients, we identified 260 patients with CIm (92 men and 168 women). Patients with CIm rated their QoL significantly worse (p< 0.05) than patients without it in 13 of MSQoL-54 battery´s 14 subscales. Men with CIm rated their QoL worse (p< 0.05) in 4 of the 14 subscales of MSQoL-54, while cognitively impaired women rated their QoL worse (p< 0.05) in 13 of the 14 subscales of MSQoL-54. Men with higher education rated their QoL worse in only 2 of the 14 subscales if they had CIm, while men with lower education did the same in 6 of the 14 subscales (p< 0.05). Women of higher education rated their QoL worse in case of CIm in 11 of the 14 subscales, while women with lower education did in 9 of the 14 subscales (p< 0.05).
Discussion: We found that CIm negatively impacts the patients´ QoL as compared to cognitively unimpaired patients in very similar physical state. It seems that CIm troubles women far more than men. Among women, the educational level does not have an effect on this, while men with lower education seems to be more affected than men with higher education. To our best knowledge, this study is the first to evaluate the differences between educational levels regarding the impact of CIm on MS patients QoL.
Disclosure:
Dániel Sandi: nothing to disclose
Tamás Biernacki: nothing to disclose
Dóra Szekeres: nothing to disclose
Judit Füvesi: nothing to disclose
Zsigmond Tamás Kincses: nothing to disclose
Csilla Rózsa: nothing to disclose
Klotild Mátyás: nothing to disclose
Krisztián Kása: nothing to disclose
Judit Matolcsi: nothing to disclose
Dóra Zboznovits: nothing to disclose
Anna Pyreschitz: nothing to disclose
Éva Langane: nothing to disclose
László Vécsei: nothing to disclose
Krisztina Bencsik: nothing to disclose
Abstract: EP1363
Type: ePoster
Abstract Category: Clinical aspects of MS - Epidemiology
Introduction: Multiple sclerosis (MS) not only causes somatic disability but often leads to psychopathological symptoms. Of these symptoms, cognitive impairment (CIm) can appear at any age and any stage of the disease. The impact of CIm on the patients" quality of life (QoL) was assessed by only a small number of evaluations. Benedict et al showed that CIm, depression and fatigue worsen the patients" QoL as much as the physical impairment. This study aimed to assess the impact of CIm on the patients´ QoL and the possible difference between genders and different levels of education.
Patients and methods: We recruited 482 patients suffering from relapsing-remitting MS or clinically isolated syndrome treated at the Department of Neurology of the University of Szeged, the Jahn Ferenc Teaching Hospital of Budapest and the Markhot Ferenc Teaching Hospital of Eger into our study. All patients were in remission for at least 30 days. We used the BICAMS battery for the assessment of their cognitive state while we administered the MSQoL-54 battery for the evaluation of their QoL. We used one-way ANOVA to assess the differences in the scores of MSQoL-54 gear to cognitive impairment, gender and education.
Results: Of the recruited 482 patients, we identified 260 patients with CIm (92 men and 168 women). Patients with CIm rated their QoL significantly worse (p< 0.05) than patients without it in 13 of MSQoL-54 battery´s 14 subscales. Men with CIm rated their QoL worse (p< 0.05) in 4 of the 14 subscales of MSQoL-54, while cognitively impaired women rated their QoL worse (p< 0.05) in 13 of the 14 subscales of MSQoL-54. Men with higher education rated their QoL worse in only 2 of the 14 subscales if they had CIm, while men with lower education did the same in 6 of the 14 subscales (p< 0.05). Women of higher education rated their QoL worse in case of CIm in 11 of the 14 subscales, while women with lower education did in 9 of the 14 subscales (p< 0.05).
Discussion: We found that CIm negatively impacts the patients´ QoL as compared to cognitively unimpaired patients in very similar physical state. It seems that CIm troubles women far more than men. Among women, the educational level does not have an effect on this, while men with lower education seems to be more affected than men with higher education. To our best knowledge, this study is the first to evaluate the differences between educational levels regarding the impact of CIm on MS patients QoL.
Disclosure:
Dániel Sandi: nothing to disclose
Tamás Biernacki: nothing to disclose
Dóra Szekeres: nothing to disclose
Judit Füvesi: nothing to disclose
Zsigmond Tamás Kincses: nothing to disclose
Csilla Rózsa: nothing to disclose
Klotild Mátyás: nothing to disclose
Krisztián Kása: nothing to disclose
Judit Matolcsi: nothing to disclose
Dóra Zboznovits: nothing to disclose
Anna Pyreschitz: nothing to disclose
Éva Langane: nothing to disclose
László Vécsei: nothing to disclose
Krisztina Bencsik: nothing to disclose