Contributions
Abstract: EP1362
Type: ePoster
Abstract Category: Clinical aspects of MS - Epidemiology
Background: There is a significant increase of Multiple Sclerosis (MS) in Tehran, the capital of Iran. There are studies that clarify the correlation between positive familial history of MS and its incidence.
Familial association is one of the important factors in MS that increase the risk of MS presentation.
Methods: A population-based survey conducted from 1999 to 2015 on 16447 registered cases of MS, based on Iranian MS Society (IMSS) registry system of Tehran. We design a questionnaire to cover the main epidemiological variables which is associated with individual level for familial MS among different relatives. Relatives were allocated to 3 categories.
In order to predict familial MS risk factors, we estimate the odds ratio (OR) for individual variable by logistic regression analysis. P values < 0.05 were considered significant.
Results: There is 12.4% Positive family history of MS among all patients, 13.0 for male and 12.2 for female. The greatest prevalence of familial MS is among first-degree relatives, especially among sibling., p value=0.001. The highest percentage of familial MS was observed in pediatric group, 18< years old 173 (15.1%) (OR ＝ 1.276; 95％ CI ＝0.904 - 1.803).
Conclusion: Familial MS is increasing every five years among patients, during our study and our results show that, Tehran have the higher percentage of patients with positive increasing family history of MS in comparison to other areas of Iran and other countries in Middle East. We detected an anticipation of younger age at onset of MS among patients with positive familial history of MS.
Disclosure: nothing to disclose
Abstract: EP1362
Type: ePoster
Abstract Category: Clinical aspects of MS - Epidemiology
Background: There is a significant increase of Multiple Sclerosis (MS) in Tehran, the capital of Iran. There are studies that clarify the correlation between positive familial history of MS and its incidence.
Familial association is one of the important factors in MS that increase the risk of MS presentation.
Methods: A population-based survey conducted from 1999 to 2015 on 16447 registered cases of MS, based on Iranian MS Society (IMSS) registry system of Tehran. We design a questionnaire to cover the main epidemiological variables which is associated with individual level for familial MS among different relatives. Relatives were allocated to 3 categories.
In order to predict familial MS risk factors, we estimate the odds ratio (OR) for individual variable by logistic regression analysis. P values < 0.05 were considered significant.
Results: There is 12.4% Positive family history of MS among all patients, 13.0 for male and 12.2 for female. The greatest prevalence of familial MS is among first-degree relatives, especially among sibling., p value=0.001. The highest percentage of familial MS was observed in pediatric group, 18< years old 173 (15.1%) (OR ＝ 1.276; 95％ CI ＝0.904 - 1.803).
Conclusion: Familial MS is increasing every five years among patients, during our study and our results show that, Tehran have the higher percentage of patients with positive increasing family history of MS in comparison to other areas of Iran and other countries in Middle East. We detected an anticipation of younger age at onset of MS among patients with positive familial history of MS.
Disclosure: nothing to disclose