Contributions
Abstract: EP1357
Type: ePoster
Abstract Category: Clinical aspects of MS - Natural course
Background: The aim of this study was to determine MRI and neurophysiological predictors of clinical and MRI disease activity within the six months of an initial demyelinating event - clinically isolated syndrome (CIS).
Methods: Fifty-eight CIS patients (43 females, mean age 32.6+/-9.8) seen within 6 months of symptoms onset were studied. Following potential predictors were analyzed: gender, brainstem lesions, cervical spinal cord lesions, autonomic dysfunction (Composite Autonomic Scoring Scale (CASS) and postural orthostatic tachycardia syndrome (POTS)). Clinical disease activity was defined if either relapse or increase of EDSS from baseline to month 6 irrespective of relapse presence. MRI disease activity was defined if new or enlarging T2 or T1 enhancing lesions were present. No evidence of disease activity (NEDA) was defined if there was no clinical and MRI disease activity.
Results: Of 58 patients, 6 had a second event, 8 had EDSS progression and 22 had MRI disease activity within 6 months. Patients with POTS at baseline (4 patients) had relative risk of 6.8 (95% CI 1.73 - 26.29) for relapse, 2.13 (95% CI 1.09 - 4.17) for MRI disease activity, and 2.16 (95% CI 1.62 - 2.88) for absence of NEDA within 6 months. For all other studied parameters we found no evidence of increased risk for disease activity within first 6 months of CIS.
Conclusion: Patients with POTS are at increased risk for clinical and/or MRI disease activity within 6 months of first demyelinating event. This finding further widens existing evidence regarding interactions between the autonomic nervous system and the immune system functions in multiple sclerosis.
Disclosure: Funding: Croatian Science Foundation grant HRZZ UIP-11-2013-2622
Abstract: EP1357
Type: ePoster
Abstract Category: Clinical aspects of MS - Natural course
Background: The aim of this study was to determine MRI and neurophysiological predictors of clinical and MRI disease activity within the six months of an initial demyelinating event - clinically isolated syndrome (CIS).
Methods: Fifty-eight CIS patients (43 females, mean age 32.6+/-9.8) seen within 6 months of symptoms onset were studied. Following potential predictors were analyzed: gender, brainstem lesions, cervical spinal cord lesions, autonomic dysfunction (Composite Autonomic Scoring Scale (CASS) and postural orthostatic tachycardia syndrome (POTS)). Clinical disease activity was defined if either relapse or increase of EDSS from baseline to month 6 irrespective of relapse presence. MRI disease activity was defined if new or enlarging T2 or T1 enhancing lesions were present. No evidence of disease activity (NEDA) was defined if there was no clinical and MRI disease activity.
Results: Of 58 patients, 6 had a second event, 8 had EDSS progression and 22 had MRI disease activity within 6 months. Patients with POTS at baseline (4 patients) had relative risk of 6.8 (95% CI 1.73 - 26.29) for relapse, 2.13 (95% CI 1.09 - 4.17) for MRI disease activity, and 2.16 (95% CI 1.62 - 2.88) for absence of NEDA within 6 months. For all other studied parameters we found no evidence of increased risk for disease activity within first 6 months of CIS.
Conclusion: Patients with POTS are at increased risk for clinical and/or MRI disease activity within 6 months of first demyelinating event. This finding further widens existing evidence regarding interactions between the autonomic nervous system and the immune system functions in multiple sclerosis.
Disclosure: Funding: Croatian Science Foundation grant HRZZ UIP-11-2013-2622