Abstract: EP1356
Type: ePoster
Abstract Category: Clinical aspects of MS - Paediatric MS
Introduction: Multiple sclerosis (MS) is typically a disease of the young adult, however, from to 2 to 10 % of cases begin before 18 years of age. The early age seems to affect the clinical aspects and evolution of MS.
Objectives: To compare the clinical aspects and outcomes of the Pediatric Multiple Sclerosis (PMS) to adult disease in a Brazilian population.
Methods: Two studies were conducted. The first, cross-sectional, showed the prevalence and demographic and clinical data of MSP out of the 809 cases of MS identified. In the second study were compared clinical and outcomes aspects between 65 patients with PMS and 260 randomly selected adult cases of relapsing- remitting MS (RRMS). Kaplan Meier analysis was performed to compared the age onset and the time for disability outcomes and secondary progression.
Results: Prevalence of PMS was 9,8% of all cases of MS. The most frequent age was 17 and patients under 10 were rare. The RRMS corresponded to 98% of cases. The recovery of the initial event was 7.8% in PMS vs. 21.8% in adults (p = 0.004). At the initial event, the motor abnormalities were more frequent in boys and the sensitive ones prevailed in females. The interval between the first and second outbreaks was longer in girls and similar between PMS and Adult MS. Benign forms were more common in the PMS (84.6% vs. 62.2%). In PMS fewer patients achieved EDSS6 (11% vs 25%) (p = 0.0017) and secondary progression (11% vs 28%) (p = 0.005) Patients with PMS took longer to reach EDSS 3
(p = 0.017), 6 (p = 0.001) and progression (P < 0.001) but reached the EDSS3 at earlier age (p < 0.001).
Conclusions: At this multiracial cohort, PMS prevalence is among descriptions of other studies, and its outcomes was more benign than in adults.
Disclosure:
Claudia C F Vasconcelos: nothing to disclose
Simone C C Pinto: nothing to disclose
Luiz Claudio Santos Thuler: nothing to disclose
Juliana C K Aurenção: nothing to disclose
Marcos Papais Alvarenga: nothing to disclose
Solange M. G G Camargo: nothing to disclose
Elizabeth Batista: nothing to disclose
Regina M. Papais-Alvarenga: nothing to disclose
Abstract: EP1356
Type: ePoster
Abstract Category: Clinical aspects of MS - Paediatric MS
Introduction: Multiple sclerosis (MS) is typically a disease of the young adult, however, from to 2 to 10 % of cases begin before 18 years of age. The early age seems to affect the clinical aspects and evolution of MS.
Objectives: To compare the clinical aspects and outcomes of the Pediatric Multiple Sclerosis (PMS) to adult disease in a Brazilian population.
Methods: Two studies were conducted. The first, cross-sectional, showed the prevalence and demographic and clinical data of MSP out of the 809 cases of MS identified. In the second study were compared clinical and outcomes aspects between 65 patients with PMS and 260 randomly selected adult cases of relapsing- remitting MS (RRMS). Kaplan Meier analysis was performed to compared the age onset and the time for disability outcomes and secondary progression.
Results: Prevalence of PMS was 9,8% of all cases of MS. The most frequent age was 17 and patients under 10 were rare. The RRMS corresponded to 98% of cases. The recovery of the initial event was 7.8% in PMS vs. 21.8% in adults (p = 0.004). At the initial event, the motor abnormalities were more frequent in boys and the sensitive ones prevailed in females. The interval between the first and second outbreaks was longer in girls and similar between PMS and Adult MS. Benign forms were more common in the PMS (84.6% vs. 62.2%). In PMS fewer patients achieved EDSS6 (11% vs 25%) (p = 0.0017) and secondary progression (11% vs 28%) (p = 0.005) Patients with PMS took longer to reach EDSS 3
(p = 0.017), 6 (p = 0.001) and progression (P < 0.001) but reached the EDSS3 at earlier age (p < 0.001).
Conclusions: At this multiracial cohort, PMS prevalence is among descriptions of other studies, and its outcomes was more benign than in adults.
Disclosure:
Claudia C F Vasconcelos: nothing to disclose
Simone C C Pinto: nothing to disclose
Luiz Claudio Santos Thuler: nothing to disclose
Juliana C K Aurenção: nothing to disclose
Marcos Papais Alvarenga: nothing to disclose
Solange M. G G Camargo: nothing to disclose
Elizabeth Batista: nothing to disclose
Regina M. Papais-Alvarenga: nothing to disclose