Contributions
Abstract: EP1355
Type: ePoster
Abstract Category: Clinical aspects of MS - Paediatric MS
Background: Pediatric Multiple Sclerosis is the term which refers to the first onset of disease before 18 years old. According to the Atlas of MS International Federation, prevalence of MS is 33 per 100,000 globally in 2013.A positive familial history of MS have been reported 3-10% of patients suffering pediatric MS in some studies. Several studies on pediatric MS have reported 6 to 23% of positive familial history which is similar to our findings. The goal of this study is determine familial history of MS among pediatric patients.
Method: A cross-sectional study, based on Iranian MS Society registry of MS patients in Tehran-Iran was assessed since 1999 until 2015. The main variables associated with different level of familial MS among 3 categories in relatives were examined.
Results: Among 1162 pediatric MS patients, female to male ratio was 3.6:1. The mean age was15.04 years old (15.13 in female and 14.70 in male respectively).
173 pediatric MS with positive familial history were identified in our survey (14.9%).
Among all patients with positive familial history of MS, 61 (5.2%) was observed among first-degree especially among siblings (p =0.000), 32 (2.8%) among second-degree especially among grandparents (p < 0.003), 54 (4.6%) among third-degree of relatives.
The maternal familial history of MS was more frequent than the paternal, 21 (1.8%), p=0.000. There was also significant difference between second-degree relatives such as maternal aunt & uncle and paternal aunt & uncle 17 (1.5%), p=0.000.
Conclusion: Our findings suggested that positive familial history of MS in maternal degree (such as mother, maternal aunt & uncle) and also siblings of the patients had more effect on the observation of familial pediatric MS.
Disclosure: The author(s) have declared that no competing interests exist.
Abstract: EP1355
Type: ePoster
Abstract Category: Clinical aspects of MS - Paediatric MS
Background: Pediatric Multiple Sclerosis is the term which refers to the first onset of disease before 18 years old. According to the Atlas of MS International Federation, prevalence of MS is 33 per 100,000 globally in 2013.A positive familial history of MS have been reported 3-10% of patients suffering pediatric MS in some studies. Several studies on pediatric MS have reported 6 to 23% of positive familial history which is similar to our findings. The goal of this study is determine familial history of MS among pediatric patients.
Method: A cross-sectional study, based on Iranian MS Society registry of MS patients in Tehran-Iran was assessed since 1999 until 2015. The main variables associated with different level of familial MS among 3 categories in relatives were examined.
Results: Among 1162 pediatric MS patients, female to male ratio was 3.6:1. The mean age was15.04 years old (15.13 in female and 14.70 in male respectively).
173 pediatric MS with positive familial history were identified in our survey (14.9%).
Among all patients with positive familial history of MS, 61 (5.2%) was observed among first-degree especially among siblings (p =0.000), 32 (2.8%) among second-degree especially among grandparents (p < 0.003), 54 (4.6%) among third-degree of relatives.
The maternal familial history of MS was more frequent than the paternal, 21 (1.8%), p=0.000. There was also significant difference between second-degree relatives such as maternal aunt & uncle and paternal aunt & uncle 17 (1.5%), p=0.000.
Conclusion: Our findings suggested that positive familial history of MS in maternal degree (such as mother, maternal aunt & uncle) and also siblings of the patients had more effect on the observation of familial pediatric MS.
Disclosure: The author(s) have declared that no competing interests exist.