Contributions
Abstract: EP1354
Type: ePoster
Abstract Category: Clinical aspects of MS - Paediatric MS
Introduction: Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system. The aim of the study was a neurophysiological characterisation of adolescent patients with relapsing-remitting MS (RRMS) eligible to receive an.
Material and methods: In this study 23 patients aged 14,9 -17,8 years have been included. According to initial symptoms two categories of patients were identified: in one group [group 1] (12/23) there were patients with focal signs such as motor and/or sensory abnormalities while the second one [group 2] (11/23) consisted of patients with retrobulbar optic neuritis.
Results: There were no significant differences in VEP latencies and amplitudes in both 1 (P100 latency=109.3±12.9ms) and 2 group (116.37±12.91ms). In both groups a significant latency prolongation as well as P100 amplitude decrease has been observed in comparison to the control group (101.57±5.55ms). Furthermore, the study has shown that the average latencies of N75 and N135 in group 2 were prolongated when compared to the control group. In SSEP examination group 1 has demonstrated a substantial latency prolongation of P14 (14.23±1.58ms), N18 (18.45±1.52ms) and N20 (19.19±1.29ms) when compared to the control group, and the same result for P14 (14.72±2.79ms), N20 (19.46±2.04ms), P25 (24.04±2.72ms) and CCT (7.04±1.04ms) has been detected in group 2. The average amplitudes of all waves in group 1 were insignificantly lower than in the control group.
In group 2 an insignificant decrease of amplitudes P9 and P18 from the control group has been noticed. In contrast, P25 amplitude was significantly lower.
Conclusions:
1. Visual evoked potentials test is an effective neurophysiological method in a diagnosis of subclinical focal demyelination in CNS.
2. The presence of changes in somatosensory evoked potentials indicates a demand for further precise diagnosis of spinal location of MS.
Disclosure: All authors declare no conflict of interest
Abstract: EP1354
Type: ePoster
Abstract Category: Clinical aspects of MS - Paediatric MS
Introduction: Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system. The aim of the study was a neurophysiological characterisation of adolescent patients with relapsing-remitting MS (RRMS) eligible to receive an.
Material and methods: In this study 23 patients aged 14,9 -17,8 years have been included. According to initial symptoms two categories of patients were identified: in one group [group 1] (12/23) there were patients with focal signs such as motor and/or sensory abnormalities while the second one [group 2] (11/23) consisted of patients with retrobulbar optic neuritis.
Results: There were no significant differences in VEP latencies and amplitudes in both 1 (P100 latency=109.3±12.9ms) and 2 group (116.37±12.91ms). In both groups a significant latency prolongation as well as P100 amplitude decrease has been observed in comparison to the control group (101.57±5.55ms). Furthermore, the study has shown that the average latencies of N75 and N135 in group 2 were prolongated when compared to the control group. In SSEP examination group 1 has demonstrated a substantial latency prolongation of P14 (14.23±1.58ms), N18 (18.45±1.52ms) and N20 (19.19±1.29ms) when compared to the control group, and the same result for P14 (14.72±2.79ms), N20 (19.46±2.04ms), P25 (24.04±2.72ms) and CCT (7.04±1.04ms) has been detected in group 2. The average amplitudes of all waves in group 1 were insignificantly lower than in the control group.
In group 2 an insignificant decrease of amplitudes P9 and P18 from the control group has been noticed. In contrast, P25 amplitude was significantly lower.
Conclusions:
1. Visual evoked potentials test is an effective neurophysiological method in a diagnosis of subclinical focal demyelination in CNS.
2. The presence of changes in somatosensory evoked potentials indicates a demand for further precise diagnosis of spinal location of MS.
Disclosure: All authors declare no conflict of interest