Contributions
Abstract: EP1348
Type: ePoster
Abstract Category: Clinical aspects of MS - MS Variants
Introduction and background: Optic neuritis is usually the first clinical symptom in neuromyelitis optica spectrum disorders (NMOSD) and relapsing remitting multiple sclerosis (MS). Optic nerve in MS could be also affected as part of global progressive degeneration. Optical coherence tomography (OCT) measures retinal nerve fiber layer (RNFL) thickness at peripapillar rim. Our aim is to analyse differences between both NMOSD and MS groups by peripapillar OCT.
Methods: We performed a cross-sectional study of ten NMOSD and ten MS patients matched by age and gender. Only patients with more than one year of disease duration and three months since last relapse where recruited. Complete neurological (EDSS and SDMT), ophtalmological exam (including slit lamp and intraocular pressure) and OCT (Heidelberg Spectralis) were carried out. The statistical model used was Generalized Estimating Equation (GEE) in MS/NMOSD group comparisons and Spearman Rho in correlations.
Results: 39 eyes were analysed. NMOSD eyes with previous optical neuritis (ON) showed similar global RNFL and by sectors than MS eyes with previous ON. Nevertheless, NMOSD eyes without previous ON got thicker global RNFL (also temporal, superior and inferior RNFL) than MS eyes without ON (101 µm versus 88 µm p< 0,001). In NMOSD patients, global and temporal RNFL thickness were correlated with number of previous ON (Rho -0,578 p=0,01 and -0,50 p=0,032) but were not associated with disease duration. However, temporal RNFL thickness in MS patients correlated with number of previous ON (-0,703 p=0,001) as well as disease duration (-0,40 p=0,091). Scores on SDMT in MS patients matched also with disease duration (-0,518y p=0,019).
Conclusions: NMOSD without previous ON don´t show significantly reduction of RNFL thickness compared to MS. Temporal RNFL only in MS eyes is associated with disease duration. Temporal RNFL loss could reflect a progressive global neuronal degeneration in MS. Longitudinal measure of temporal RNFL after three months of ON could help us in distinguishing NMOSD from MS disease.
Disclosure:
Aida Orviz García: nothing to disclose
Inés González Suárez: nothing to disclose
Victoria López de Velasco: nothing to disclose
Marta Palacios Sarmiento: nothing to disclose
Celia Oreja Guevara: nothing to disclose
Abstract: EP1348
Type: ePoster
Abstract Category: Clinical aspects of MS - MS Variants
Introduction and background: Optic neuritis is usually the first clinical symptom in neuromyelitis optica spectrum disorders (NMOSD) and relapsing remitting multiple sclerosis (MS). Optic nerve in MS could be also affected as part of global progressive degeneration. Optical coherence tomography (OCT) measures retinal nerve fiber layer (RNFL) thickness at peripapillar rim. Our aim is to analyse differences between both NMOSD and MS groups by peripapillar OCT.
Methods: We performed a cross-sectional study of ten NMOSD and ten MS patients matched by age and gender. Only patients with more than one year of disease duration and three months since last relapse where recruited. Complete neurological (EDSS and SDMT), ophtalmological exam (including slit lamp and intraocular pressure) and OCT (Heidelberg Spectralis) were carried out. The statistical model used was Generalized Estimating Equation (GEE) in MS/NMOSD group comparisons and Spearman Rho in correlations.
Results: 39 eyes were analysed. NMOSD eyes with previous optical neuritis (ON) showed similar global RNFL and by sectors than MS eyes with previous ON. Nevertheless, NMOSD eyes without previous ON got thicker global RNFL (also temporal, superior and inferior RNFL) than MS eyes without ON (101 µm versus 88 µm p< 0,001). In NMOSD patients, global and temporal RNFL thickness were correlated with number of previous ON (Rho -0,578 p=0,01 and -0,50 p=0,032) but were not associated with disease duration. However, temporal RNFL thickness in MS patients correlated with number of previous ON (-0,703 p=0,001) as well as disease duration (-0,40 p=0,091). Scores on SDMT in MS patients matched also with disease duration (-0,518y p=0,019).
Conclusions: NMOSD without previous ON don´t show significantly reduction of RNFL thickness compared to MS. Temporal RNFL only in MS eyes is associated with disease duration. Temporal RNFL loss could reflect a progressive global neuronal degeneration in MS. Longitudinal measure of temporal RNFL after three months of ON could help us in distinguishing NMOSD from MS disease.
Disclosure:
Aida Orviz García: nothing to disclose
Inés González Suárez: nothing to disclose
Victoria López de Velasco: nothing to disclose
Marta Palacios Sarmiento: nothing to disclose
Celia Oreja Guevara: nothing to disclose