Contributions
Abstract: EP1344
Type: ePoster
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Introduction: Nowadays the knowledge of mutiple sclerosis (MS) and Neuro-Behçet disease (NBD have considerably grown, but it is still a situations where almost similar cases still pose the problem of differential diagnosis. The purpose of this work is to highlight the similarities and the differences between those two diseases by comparing them.
Materials and methods: It is a descriptive and retrospective study, which started from January 1st, 2009 to December 31th, 2015 and concerned a cohort of 60 patients followed up for MS and 40 patients for NBD. Only the parenchymal forms of Neuro-Behçet were included in the study.
Results: Among the 40 cases of the NB and the 60 cases of the MS, respectively 22 and 20 were males, 18 and 40 were females. The sex ratio was at 1.2 for the NB (M/F) and at 2.0 for the MS (F/M).
The most clinical common finding was the pyramidal signs in 27 NB cases (67%) and in 45 MS cases (75%). In second position we found a cerebellar syndrome in 22 NB patients (55%) and 42 MS cases (70%). 20 NB patients (50%) showed a different cranial nerves against 18 MS cases (30%); A posterior cordonal syndrome was noticed in 39 MS cases (65%) and in 12.5 of the NB patients. 9 optic neuropathy cases (22.5%), which 2 retrobulbar optic neuritis cases (5%) was observed in the NB against 23 retrobulbar optic neuritis cases during MS (38%).
In the MS group, the most common clinical form was the remittent form with a percentage of 85%. In the NB group, the evolutive tempo of the patients was most often a progressive mode in 67.5% of the cases.
The oligoclonal bands were presented in 85% of the MS patients and 17% of the NB cases.
The demyelinating MRI lesions affected the brain stem (52.5% NB - 86% MS), the cerebellum (32.5% NB - 90% MS), the basal ganglia (30% NB - 05% MS), the oval center (32.5% NB- 80% MS) and the corpus callosum (12.5% NB - 86% MS). We found a small disseminated lesions of the hemispheric subcortical white matter (40% NB - 91.7% MS) and in a periventricular (42.5% NB - 98.3% MS). The internal capsule lesion was exclusively observed in the NB.
Discussion: Many clinical studies have been devoted to these two diseases before but independently and there are very few comparative studies across the world. We have selected the most relevant articles to illustrate our study.
Conclusion: The diagnosis of multiple sclerosis and Neuro-behçet"s disease remain in elimination diagnosis, because both diseases are devoid of specific biomarkers.
Disclosure: Nothing to Disclosure
Abstract: EP1344
Type: ePoster
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Introduction: Nowadays the knowledge of mutiple sclerosis (MS) and Neuro-Behçet disease (NBD have considerably grown, but it is still a situations where almost similar cases still pose the problem of differential diagnosis. The purpose of this work is to highlight the similarities and the differences between those two diseases by comparing them.
Materials and methods: It is a descriptive and retrospective study, which started from January 1st, 2009 to December 31th, 2015 and concerned a cohort of 60 patients followed up for MS and 40 patients for NBD. Only the parenchymal forms of Neuro-Behçet were included in the study.
Results: Among the 40 cases of the NB and the 60 cases of the MS, respectively 22 and 20 were males, 18 and 40 were females. The sex ratio was at 1.2 for the NB (M/F) and at 2.0 for the MS (F/M).
The most clinical common finding was the pyramidal signs in 27 NB cases (67%) and in 45 MS cases (75%). In second position we found a cerebellar syndrome in 22 NB patients (55%) and 42 MS cases (70%). 20 NB patients (50%) showed a different cranial nerves against 18 MS cases (30%); A posterior cordonal syndrome was noticed in 39 MS cases (65%) and in 12.5 of the NB patients. 9 optic neuropathy cases (22.5%), which 2 retrobulbar optic neuritis cases (5%) was observed in the NB against 23 retrobulbar optic neuritis cases during MS (38%).
In the MS group, the most common clinical form was the remittent form with a percentage of 85%. In the NB group, the evolutive tempo of the patients was most often a progressive mode in 67.5% of the cases.
The oligoclonal bands were presented in 85% of the MS patients and 17% of the NB cases.
The demyelinating MRI lesions affected the brain stem (52.5% NB - 86% MS), the cerebellum (32.5% NB - 90% MS), the basal ganglia (30% NB - 05% MS), the oval center (32.5% NB- 80% MS) and the corpus callosum (12.5% NB - 86% MS). We found a small disseminated lesions of the hemispheric subcortical white matter (40% NB - 91.7% MS) and in a periventricular (42.5% NB - 98.3% MS). The internal capsule lesion was exclusively observed in the NB.
Discussion: Many clinical studies have been devoted to these two diseases before but independently and there are very few comparative studies across the world. We have selected the most relevant articles to illustrate our study.
Conclusion: The diagnosis of multiple sclerosis and Neuro-behçet"s disease remain in elimination diagnosis, because both diseases are devoid of specific biomarkers.
Disclosure: Nothing to Disclosure