Contributions
Abstract: EP1341
Type: ePoster
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Background: Optic neuritis (ON) is a main presenting symptom of neuromyelitis optica (NMO) and multiple sclerosis (MS). However, the ON in these diseases has some different features. Damage to astrocytes by anti-aquaporin-4 antibody (NMO-Ab) has been implicated as the cause of NMO. Oligoclonal band (OCB) pattern of cerebrospinal fluid (CSF) is indicated the respection of autoimmune aetiology in MS. Inspite of the data, NMO-Ab in sera and OCB in CSF are negative in some patients with NMO/NMOSD-ON or MS-ON. On the other hand, myelin oligodendrocyte glycoprotein (MOG) is well known as the causative protein of MS.
Aim: To determine the relationship between immunological parameters (NMO-Ab, OCB pattern and antiMOG-Ab) and clinical features and visual functions in NMO/ NMOSD and MS patients with ON.
Results: 14 NMO/NMOSD (28 eyes/24 ONH+) and 24 MS (46 eyes/31ONH+) were evaluated. AntiMOG-Ab and Anti-AQP4Ab were tested in sera of all patients with a cell based assay at the Euroimmune laboratory in Germany. Both the number of affected eyes and severe visual loss in NMO/NMOSD group were clinically more than MSON group. Four (28 %) of 14 NMO-ON patients were NMO-Ab seropositive and OCB (-) in all, while 11 (47%) of the 24 MSON patients were OCB (-) and NMO-Ab(-) in all. Anti-MOG-Ab positivity was only found in 2 patients with NMO/NMOSD-ON. Both patients were NMO-Ab seronegative and OCB (-) patients.Visual loss was bilateral and severe, and one of them had recurrent ON.
Conclusions: AntiMOG-Ab were found negative in all MSON group and NMO/NMOSD ON patients with NMO-Ab seropositive. Anti-MOG-Ab positivity was only established in 20 % of NMO/NMOSD-ON patients being NMO-Ab(-). Although these findings could not directly contribute to an understanding of differential diagnosis and pathogenesis of both diseases, at least the AntiMOG-Ab titration can be used in the diagnosis of some cases with NMO-IgG negativity. On the other hand, visual loss of antiMOG (+) patients was heavier in contrast to the literature. Nevertheless, large and different disagned groups would be more effective to determine the relationship between immunological parameters and visual functions and pathogenesis.
Disclosure:
Fethi Idiman: Nothing to disclose
Egemen Idiman: Nothing to disclose
Derya Kaya: Nothing to disclose
Omercan Hasakoyoglu: Nothing to disclose
Betul Tercan: Nothing to disclose
Pınar Ozcelik: Nothing to disclose
Zekiye Altun: Nothing to disclose
Source of funding: None
Abstract: EP1341
Type: ePoster
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Background: Optic neuritis (ON) is a main presenting symptom of neuromyelitis optica (NMO) and multiple sclerosis (MS). However, the ON in these diseases has some different features. Damage to astrocytes by anti-aquaporin-4 antibody (NMO-Ab) has been implicated as the cause of NMO. Oligoclonal band (OCB) pattern of cerebrospinal fluid (CSF) is indicated the respection of autoimmune aetiology in MS. Inspite of the data, NMO-Ab in sera and OCB in CSF are negative in some patients with NMO/NMOSD-ON or MS-ON. On the other hand, myelin oligodendrocyte glycoprotein (MOG) is well known as the causative protein of MS.
Aim: To determine the relationship between immunological parameters (NMO-Ab, OCB pattern and antiMOG-Ab) and clinical features and visual functions in NMO/ NMOSD and MS patients with ON.
Results: 14 NMO/NMOSD (28 eyes/24 ONH+) and 24 MS (46 eyes/31ONH+) were evaluated. AntiMOG-Ab and Anti-AQP4Ab were tested in sera of all patients with a cell based assay at the Euroimmune laboratory in Germany. Both the number of affected eyes and severe visual loss in NMO/NMOSD group were clinically more than MSON group. Four (28 %) of 14 NMO-ON patients were NMO-Ab seropositive and OCB (-) in all, while 11 (47%) of the 24 MSON patients were OCB (-) and NMO-Ab(-) in all. Anti-MOG-Ab positivity was only found in 2 patients with NMO/NMOSD-ON. Both patients were NMO-Ab seronegative and OCB (-) patients.Visual loss was bilateral and severe, and one of them had recurrent ON.
Conclusions: AntiMOG-Ab were found negative in all MSON group and NMO/NMOSD ON patients with NMO-Ab seropositive. Anti-MOG-Ab positivity was only established in 20 % of NMO/NMOSD-ON patients being NMO-Ab(-). Although these findings could not directly contribute to an understanding of differential diagnosis and pathogenesis of both diseases, at least the AntiMOG-Ab titration can be used in the diagnosis of some cases with NMO-IgG negativity. On the other hand, visual loss of antiMOG (+) patients was heavier in contrast to the literature. Nevertheless, large and different disagned groups would be more effective to determine the relationship between immunological parameters and visual functions and pathogenesis.
Disclosure:
Fethi Idiman: Nothing to disclose
Egemen Idiman: Nothing to disclose
Derya Kaya: Nothing to disclose
Omercan Hasakoyoglu: Nothing to disclose
Betul Tercan: Nothing to disclose
Pınar Ozcelik: Nothing to disclose
Zekiye Altun: Nothing to disclose
Source of funding: None