Contributions
Abstract: EP1340
Type: ePoster
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Objectives: Increased neurovascular coupling (NVC) might be considered as playing a role in the pathogenesis of multiple sclerosis or a consequence of the demyelination and degeneration. However, the altered neurovascular coupling has not been known in patients with cerebral vasculitis no matter primary or secondary. The objective of this study is to assess the NVC of patients with relapsing-remitting multiple sclerosis (RRMS) and compare to patients with secondary cerebral vasculitis (SCV) during the acute exacerbation periods of the diseases.
Patients and methods: Seventy-eight patients with RRMS and 24 patients with SCV were included in this study during the last ten years. We performed trans-temporal transcranial Doppler recordings from the P2-segments of both posterior cerebral arteries simultaneously during complex visual stimulation. The NVC was defined as a relative increase of the blood flow velocities during visual stimulation.
Results: The NVC to complex visual stimulation was significantly lower in the patients with SCV (35.7±6.1% and 33.7±5.8%; right and left side, respectively; p=0.001) from those of the patients with RRMS (42.6±14.4% and 39.6±14.4%; right and left side, respectively; p=0.004).
Conclusion: Our results suggest that patients with SCV during the acute period have less reactive neurovascular units in the occipital cortex compare to the patients with RRMS during acute attack period.
Disclosure: Tekgol Uzuner G: Nothing to disclose
Uzuner N: Nothing to disclose
Abstract: EP1340
Type: ePoster
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Objectives: Increased neurovascular coupling (NVC) might be considered as playing a role in the pathogenesis of multiple sclerosis or a consequence of the demyelination and degeneration. However, the altered neurovascular coupling has not been known in patients with cerebral vasculitis no matter primary or secondary. The objective of this study is to assess the NVC of patients with relapsing-remitting multiple sclerosis (RRMS) and compare to patients with secondary cerebral vasculitis (SCV) during the acute exacerbation periods of the diseases.
Patients and methods: Seventy-eight patients with RRMS and 24 patients with SCV were included in this study during the last ten years. We performed trans-temporal transcranial Doppler recordings from the P2-segments of both posterior cerebral arteries simultaneously during complex visual stimulation. The NVC was defined as a relative increase of the blood flow velocities during visual stimulation.
Results: The NVC to complex visual stimulation was significantly lower in the patients with SCV (35.7±6.1% and 33.7±5.8%; right and left side, respectively; p=0.001) from those of the patients with RRMS (42.6±14.4% and 39.6±14.4%; right and left side, respectively; p=0.004).
Conclusion: Our results suggest that patients with SCV during the acute period have less reactive neurovascular units in the occipital cortex compare to the patients with RRMS during acute attack period.
Disclosure: Tekgol Uzuner G: Nothing to disclose
Uzuner N: Nothing to disclose